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Investigating TSPO levels in occupation-related posttraumatic stress disorder

Microglia are immune brain cells implicated in stress-related mental illnesses including posttraumatic stress disorder (PTSD). Their role in the pathophysiology of PTSD, and on neurobiological systems that regulate stress, is not completely understood. We tested the hypothesis that microglia activat...

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Autores principales: Watling, Sarah E., Gill, Talwinder, Gaudette, Erin V., Richardson, J. Don, McCluskey, Tina, Tong, Junchao, Meyer, Jeffrey H., Warsh, Jerry, Jetly, Rakesh, Hutchison, Michael G., Rhind, Shawn G., Houle, Sylvain, Kish, Stephen J., Boileau, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10041517/
https://www.ncbi.nlm.nih.gov/pubmed/36973385
http://dx.doi.org/10.1038/s41598-023-31327-y
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author Watling, Sarah E.
Gill, Talwinder
Gaudette, Erin V.
Richardson, J. Don
McCluskey, Tina
Tong, Junchao
Meyer, Jeffrey H.
Warsh, Jerry
Jetly, Rakesh
Hutchison, Michael G.
Rhind, Shawn G.
Houle, Sylvain
Kish, Stephen J.
Boileau, Isabelle
author_facet Watling, Sarah E.
Gill, Talwinder
Gaudette, Erin V.
Richardson, J. Don
McCluskey, Tina
Tong, Junchao
Meyer, Jeffrey H.
Warsh, Jerry
Jetly, Rakesh
Hutchison, Michael G.
Rhind, Shawn G.
Houle, Sylvain
Kish, Stephen J.
Boileau, Isabelle
author_sort Watling, Sarah E.
collection PubMed
description Microglia are immune brain cells implicated in stress-related mental illnesses including posttraumatic stress disorder (PTSD). Their role in the pathophysiology of PTSD, and on neurobiological systems that regulate stress, is not completely understood. We tested the hypothesis that microglia activation, in fronto-limbic brain regions involved in PTSD, would be elevated in participants with occupation-related PTSD. We also explored the relationship between cortisol and microglia activation. Twenty participants with PTSD and 23 healthy controls (HC) completed positron emission tomography (PET) scanning of the 18-kDa translocator protein (TSPO), a putative biomarker of microglia activation using the probe [(18)F]FEPPA, and blood samples for measurement of cortisol. [(18)F]FEPPA V(T) was non-significantly elevated (6.5–30%) in fronto-limbic regions in PTSD participants. [(18)F]FEPPA V(T) was significantly higher in PTSD participants reporting frequent cannabis use compared to PTSD non-users (44%, p = 0.047). Male participants with PTSD (21%, p = 0.094) and a history of early childhood trauma (33%, p = 0.116) had non-significantly higher [(18)F]FEPPA V(T). Average fronto-limbic [(18)F]FEPPA V(T) was positively related to cortisol (r = 0.530, p = 0.028) in the PTSD group only. Although we did not find a significant abnormality in TSPO binding in PTSD, findings suggest microglial activation might have occurred in a subgroup who reported frequent cannabis use. The relationship between cortisol and TSPO binding suggests a potential link between hypothalamic–pituitary–adrenal-axis dysregulation and central immune response to trauma which warrants further study.
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spelling pubmed-100415172023-03-27 Investigating TSPO levels in occupation-related posttraumatic stress disorder Watling, Sarah E. Gill, Talwinder Gaudette, Erin V. Richardson, J. Don McCluskey, Tina Tong, Junchao Meyer, Jeffrey H. Warsh, Jerry Jetly, Rakesh Hutchison, Michael G. Rhind, Shawn G. Houle, Sylvain Kish, Stephen J. Boileau, Isabelle Sci Rep Article Microglia are immune brain cells implicated in stress-related mental illnesses including posttraumatic stress disorder (PTSD). Their role in the pathophysiology of PTSD, and on neurobiological systems that regulate stress, is not completely understood. We tested the hypothesis that microglia activation, in fronto-limbic brain regions involved in PTSD, would be elevated in participants with occupation-related PTSD. We also explored the relationship between cortisol and microglia activation. Twenty participants with PTSD and 23 healthy controls (HC) completed positron emission tomography (PET) scanning of the 18-kDa translocator protein (TSPO), a putative biomarker of microglia activation using the probe [(18)F]FEPPA, and blood samples for measurement of cortisol. [(18)F]FEPPA V(T) was non-significantly elevated (6.5–30%) in fronto-limbic regions in PTSD participants. [(18)F]FEPPA V(T) was significantly higher in PTSD participants reporting frequent cannabis use compared to PTSD non-users (44%, p = 0.047). Male participants with PTSD (21%, p = 0.094) and a history of early childhood trauma (33%, p = 0.116) had non-significantly higher [(18)F]FEPPA V(T). Average fronto-limbic [(18)F]FEPPA V(T) was positively related to cortisol (r = 0.530, p = 0.028) in the PTSD group only. Although we did not find a significant abnormality in TSPO binding in PTSD, findings suggest microglial activation might have occurred in a subgroup who reported frequent cannabis use. The relationship between cortisol and TSPO binding suggests a potential link between hypothalamic–pituitary–adrenal-axis dysregulation and central immune response to trauma which warrants further study. Nature Publishing Group UK 2023-03-27 /pmc/articles/PMC10041517/ /pubmed/36973385 http://dx.doi.org/10.1038/s41598-023-31327-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Watling, Sarah E.
Gill, Talwinder
Gaudette, Erin V.
Richardson, J. Don
McCluskey, Tina
Tong, Junchao
Meyer, Jeffrey H.
Warsh, Jerry
Jetly, Rakesh
Hutchison, Michael G.
Rhind, Shawn G.
Houle, Sylvain
Kish, Stephen J.
Boileau, Isabelle
Investigating TSPO levels in occupation-related posttraumatic stress disorder
title Investigating TSPO levels in occupation-related posttraumatic stress disorder
title_full Investigating TSPO levels in occupation-related posttraumatic stress disorder
title_fullStr Investigating TSPO levels in occupation-related posttraumatic stress disorder
title_full_unstemmed Investigating TSPO levels in occupation-related posttraumatic stress disorder
title_short Investigating TSPO levels in occupation-related posttraumatic stress disorder
title_sort investigating tspo levels in occupation-related posttraumatic stress disorder
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10041517/
https://www.ncbi.nlm.nih.gov/pubmed/36973385
http://dx.doi.org/10.1038/s41598-023-31327-y
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