Molecular origins of mutational spectra produced by the environmental carcinogen N-nitrosodimethylamine and S(N)1 chemotherapeutic agents

DNA-methylating environmental carcinogens such as N-nitrosodimethylamine (NDMA) and certain alkylators used in chemotherapy form O(6)-methylguanine (m6G) as a functionally critical intermediate. NDMA is a multi-organ carcinogen found in contaminated water, polluted air, preserved foods, tobacco prod...

Descripción completa

Detalles Bibliográficos
Autores principales: Armijo, Amanda L, Thongararm, Pennapa, Fedeles, Bogdan I, Yau, Judy, Kay, Jennifer E, Corrigan, Joshua J, Chancharoen, Marisa, Chawanthayatham, Supawadee, Samson, Leona D, Carrasco, Sebastian E, Engelward, Bevin P, Fox, James G, Croy, Robert G, Essigmann, John M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
DNA Damage Sensing and Repair
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10041537/
https://www.ncbi.nlm.nih.gov/pubmed/36992846
http://dx.doi.org/10.1093/narcan/zcad015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10041537/
https://www.ncbi.nlm.nih.gov/pubmed/36992846
http://dx.doi.org/10.1093/narcan/zcad015

Ejemplares similares