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Molecular origins of mutational spectra produced by the environmental carcinogen N-nitrosodimethylamine and S(N)1 chemotherapeutic agents
DNA-methylating environmental carcinogens such as N-nitrosodimethylamine (NDMA) and certain alkylators used in chemotherapy form O(6)-methylguanine (m6G) as a functionally critical intermediate. NDMA is a multi-organ carcinogen found in contaminated water, polluted air, preserved foods, tobacco prod...
Autores principales: | Armijo, Amanda L, Thongararm, Pennapa, Fedeles, Bogdan I, Yau, Judy, Kay, Jennifer E, Corrigan, Joshua J, Chancharoen, Marisa, Chawanthayatham, Supawadee, Samson, Leona D, Carrasco, Sebastian E, Engelward, Bevin P, Fox, James G, Croy, Robert G, Essigmann, John M |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10041537/ https://www.ncbi.nlm.nih.gov/pubmed/36992846 http://dx.doi.org/10.1093/narcan/zcad015 |
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