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The Implication of Short-Chain Fatty Acids in Obesity and Diabetes
Evidence indicates that short-chain fatty acids (SCFAs) generated from the gut microbiota play crucial roles in host metabolism. They contribute to metabolic regulation and energy acquisition of the host by influencing the development of metabolic disorders. This review aims to synthesize recent adv...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10041598/ https://www.ncbi.nlm.nih.gov/pubmed/36994236 http://dx.doi.org/10.1177/11786361231162720 |
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author | Anachad, Oumaima Taouil, Amine Taha, Wafaa Bennis, Faiza Chegdani, Fatima |
author_facet | Anachad, Oumaima Taouil, Amine Taha, Wafaa Bennis, Faiza Chegdani, Fatima |
author_sort | Anachad, Oumaima |
collection | PubMed |
description | Evidence indicates that short-chain fatty acids (SCFAs) generated from the gut microbiota play crucial roles in host metabolism. They contribute to metabolic regulation and energy acquisition of the host by influencing the development of metabolic disorders. This review aims to synthesize recent advances from the literature to investigate the implication of SCFAs in the modulation of obesity and diabetes pathologies. For a better understanding of the relationships between SCFAs and host metabolism, we need to answer some questions: What is the biochemistry of SCFAs, and how they are generated by gut microbiota? What are the bacteria producing of SCFAs and from which routes? How SCFAs are absorbed and transported in the gut by different mechanisms and receptors? How SCFAs involved in obesity and diabetes pathologies? |
format | Online Article Text |
id | pubmed-10041598 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-100415982023-03-28 The Implication of Short-Chain Fatty Acids in Obesity and Diabetes Anachad, Oumaima Taouil, Amine Taha, Wafaa Bennis, Faiza Chegdani, Fatima Microbiol Insights Review Evidence indicates that short-chain fatty acids (SCFAs) generated from the gut microbiota play crucial roles in host metabolism. They contribute to metabolic regulation and energy acquisition of the host by influencing the development of metabolic disorders. This review aims to synthesize recent advances from the literature to investigate the implication of SCFAs in the modulation of obesity and diabetes pathologies. For a better understanding of the relationships between SCFAs and host metabolism, we need to answer some questions: What is the biochemistry of SCFAs, and how they are generated by gut microbiota? What are the bacteria producing of SCFAs and from which routes? How SCFAs are absorbed and transported in the gut by different mechanisms and receptors? How SCFAs involved in obesity and diabetes pathologies? SAGE Publications 2023-03-25 /pmc/articles/PMC10041598/ /pubmed/36994236 http://dx.doi.org/10.1177/11786361231162720 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Review Anachad, Oumaima Taouil, Amine Taha, Wafaa Bennis, Faiza Chegdani, Fatima The Implication of Short-Chain Fatty Acids in Obesity and Diabetes |
title | The Implication of Short-Chain Fatty Acids in Obesity and Diabetes |
title_full | The Implication of Short-Chain Fatty Acids in Obesity and Diabetes |
title_fullStr | The Implication of Short-Chain Fatty Acids in Obesity and Diabetes |
title_full_unstemmed | The Implication of Short-Chain Fatty Acids in Obesity and Diabetes |
title_short | The Implication of Short-Chain Fatty Acids in Obesity and Diabetes |
title_sort | implication of short-chain fatty acids in obesity and diabetes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10041598/ https://www.ncbi.nlm.nih.gov/pubmed/36994236 http://dx.doi.org/10.1177/11786361231162720 |
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