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The Implication of Short-Chain Fatty Acids in Obesity and Diabetes

Evidence indicates that short-chain fatty acids (SCFAs) generated from the gut microbiota play crucial roles in host metabolism. They contribute to metabolic regulation and energy acquisition of the host by influencing the development of metabolic disorders. This review aims to synthesize recent adv...

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Autores principales: Anachad, Oumaima, Taouil, Amine, Taha, Wafaa, Bennis, Faiza, Chegdani, Fatima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10041598/
https://www.ncbi.nlm.nih.gov/pubmed/36994236
http://dx.doi.org/10.1177/11786361231162720
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author Anachad, Oumaima
Taouil, Amine
Taha, Wafaa
Bennis, Faiza
Chegdani, Fatima
author_facet Anachad, Oumaima
Taouil, Amine
Taha, Wafaa
Bennis, Faiza
Chegdani, Fatima
author_sort Anachad, Oumaima
collection PubMed
description Evidence indicates that short-chain fatty acids (SCFAs) generated from the gut microbiota play crucial roles in host metabolism. They contribute to metabolic regulation and energy acquisition of the host by influencing the development of metabolic disorders. This review aims to synthesize recent advances from the literature to investigate the implication of SCFAs in the modulation of obesity and diabetes pathologies. For a better understanding of the relationships between SCFAs and host metabolism, we need to answer some questions: What is the biochemistry of SCFAs, and how they are generated by gut microbiota? What are the bacteria producing of SCFAs and from which routes? How SCFAs are absorbed and transported in the gut by different mechanisms and receptors? How SCFAs involved in obesity and diabetes pathologies?
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spelling pubmed-100415982023-03-28 The Implication of Short-Chain Fatty Acids in Obesity and Diabetes Anachad, Oumaima Taouil, Amine Taha, Wafaa Bennis, Faiza Chegdani, Fatima Microbiol Insights Review Evidence indicates that short-chain fatty acids (SCFAs) generated from the gut microbiota play crucial roles in host metabolism. They contribute to metabolic regulation and energy acquisition of the host by influencing the development of metabolic disorders. This review aims to synthesize recent advances from the literature to investigate the implication of SCFAs in the modulation of obesity and diabetes pathologies. For a better understanding of the relationships between SCFAs and host metabolism, we need to answer some questions: What is the biochemistry of SCFAs, and how they are generated by gut microbiota? What are the bacteria producing of SCFAs and from which routes? How SCFAs are absorbed and transported in the gut by different mechanisms and receptors? How SCFAs involved in obesity and diabetes pathologies? SAGE Publications 2023-03-25 /pmc/articles/PMC10041598/ /pubmed/36994236 http://dx.doi.org/10.1177/11786361231162720 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Review
Anachad, Oumaima
Taouil, Amine
Taha, Wafaa
Bennis, Faiza
Chegdani, Fatima
The Implication of Short-Chain Fatty Acids in Obesity and Diabetes
title The Implication of Short-Chain Fatty Acids in Obesity and Diabetes
title_full The Implication of Short-Chain Fatty Acids in Obesity and Diabetes
title_fullStr The Implication of Short-Chain Fatty Acids in Obesity and Diabetes
title_full_unstemmed The Implication of Short-Chain Fatty Acids in Obesity and Diabetes
title_short The Implication of Short-Chain Fatty Acids in Obesity and Diabetes
title_sort implication of short-chain fatty acids in obesity and diabetes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10041598/
https://www.ncbi.nlm.nih.gov/pubmed/36994236
http://dx.doi.org/10.1177/11786361231162720
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