Why 6-Iodouridine Cannot Be Used as a Radiosensitizer of DNA Damage? Computational and Experimental Studies

[Image: see text] Previous density functional theory (DFT) studies on 6-brominated pyrimidine nucleosides suggest that 6-iodo-2′-deoxyuridine (6IdU) should act as a better radiosensitizer than its 5-iodosubstituted 2′-deoxyuridine analogue. In this work, we show that 6IdU is unstable in an aqueous s...

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Detalles Bibliográficos
Autores principales: Falkiewicz, Karina, Kozak, Witold, Zdrowowicz, Magdalena, Spisz, Paulina, Chomicz-Mańka, Lidia, Torchala, Mieczyslaw, Rak, Janusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10041638/
https://www.ncbi.nlm.nih.gov/pubmed/36893332
http://dx.doi.org/10.1021/acs.jpcb.3c00548

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10041638/
https://www.ncbi.nlm.nih.gov/pubmed/36893332
http://dx.doi.org/10.1021/acs.jpcb.3c00548

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