PP6 regulation of Aurora A–TPX2 limits NDC80 phosphorylation and mitotic spindle size

Amplification of the mitotic kinase Aurora A or loss of its regulator protein phosphatase 6 (PP6) have emerged as drivers of genome instability. Cells lacking PPP6C, the catalytic subunit of PP6, have amplified Aurora A activity, and as we show here, enlarged mitotic spindles which fail to hold chro...

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Detalles Bibliográficos
Autores principales: Sobajima, Tomoaki, Kowalczyk, Katarzyna M., Skylakakis, Stefanos, Hayward, Daniel, Fulcher, Luke J., Neary, Colette, Batley, Caleb, Kurlekar, Samvid, Roberts, Emile, Gruneberg, Ulrike, Barr, Francis A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10041653/
https://www.ncbi.nlm.nih.gov/pubmed/36897279
http://dx.doi.org/10.1083/jcb.202205117

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