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Successful treatment of Hidradenitis Suppurativa with tofacitinib: two cases and a review of the literature
Hidradenitis Suppurativa (HS) is a major public health challenge affecting people globally, which is painful and the hard lumps under the skin are prone to infection. We aimed to investigate whether tofacitinib can help people with HS in a safe and effective way. In this study, we report two cases d...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10041958/ https://www.ncbi.nlm.nih.gov/pubmed/36993826 http://dx.doi.org/10.1093/omcr/omad003 |
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author | Sadeghzadeh Bazargan, Afsaneh Pashaei, Arezoo Goodarzi, Azadeh |
author_facet | Sadeghzadeh Bazargan, Afsaneh Pashaei, Arezoo Goodarzi, Azadeh |
author_sort | Sadeghzadeh Bazargan, Afsaneh |
collection | PubMed |
description | Hidradenitis Suppurativa (HS) is a major public health challenge affecting people globally, which is painful and the hard lumps under the skin are prone to infection. We aimed to investigate whether tofacitinib can help people with HS in a safe and effective way. In this study, we report two cases diagnosed with HS. Tofacitinib was used as a part of the treatment plan. The first patient received 5 mg of tofacitinib twice daily, 36 weeks, and the second one for 24 weeks. Clinical outcomes are described. The efficacy of tofacitinib in HS was confirmed in our study. The clinical characteristics of the patients improved after receiving tofacitinib. Lesions discharge significantly reduced, particularly in the axillary area. Tofacitinib may be useful as an adjuvant therapy when used in combination with other treatments. Further research in this area is required to improve our understanding of treatment with tofacitinib at HS. |
format | Online Article Text |
id | pubmed-10041958 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-100419582023-03-28 Successful treatment of Hidradenitis Suppurativa with tofacitinib: two cases and a review of the literature Sadeghzadeh Bazargan, Afsaneh Pashaei, Arezoo Goodarzi, Azadeh Oxf Med Case Reports Case Report Hidradenitis Suppurativa (HS) is a major public health challenge affecting people globally, which is painful and the hard lumps under the skin are prone to infection. We aimed to investigate whether tofacitinib can help people with HS in a safe and effective way. In this study, we report two cases diagnosed with HS. Tofacitinib was used as a part of the treatment plan. The first patient received 5 mg of tofacitinib twice daily, 36 weeks, and the second one for 24 weeks. Clinical outcomes are described. The efficacy of tofacitinib in HS was confirmed in our study. The clinical characteristics of the patients improved after receiving tofacitinib. Lesions discharge significantly reduced, particularly in the axillary area. Tofacitinib may be useful as an adjuvant therapy when used in combination with other treatments. Further research in this area is required to improve our understanding of treatment with tofacitinib at HS. Oxford University Press 2023-03-25 /pmc/articles/PMC10041958/ /pubmed/36993826 http://dx.doi.org/10.1093/omcr/omad003 Text en © The Author(s) 2023. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Sadeghzadeh Bazargan, Afsaneh Pashaei, Arezoo Goodarzi, Azadeh Successful treatment of Hidradenitis Suppurativa with tofacitinib: two cases and a review of the literature |
title | Successful treatment of Hidradenitis Suppurativa with tofacitinib: two cases and a review of the literature |
title_full | Successful treatment of Hidradenitis Suppurativa with tofacitinib: two cases and a review of the literature |
title_fullStr | Successful treatment of Hidradenitis Suppurativa with tofacitinib: two cases and a review of the literature |
title_full_unstemmed | Successful treatment of Hidradenitis Suppurativa with tofacitinib: two cases and a review of the literature |
title_short | Successful treatment of Hidradenitis Suppurativa with tofacitinib: two cases and a review of the literature |
title_sort | successful treatment of hidradenitis suppurativa with tofacitinib: two cases and a review of the literature |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10041958/ https://www.ncbi.nlm.nih.gov/pubmed/36993826 http://dx.doi.org/10.1093/omcr/omad003 |
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