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A mathematical model for transmission dynamics of COVID-19 infection

In this paper, a mathematical model of COVID-19 has been proposed to study the transmission dynamics of infection by taking into account the role of symptomatic and asymptomatic infected individuals. The model has also considered the effect of non-pharmaceutical interventions (NPIs) in controlling t...

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Autor principal: Awasthi, Arti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042114/
https://www.ncbi.nlm.nih.gov/pubmed/37008754
http://dx.doi.org/10.1140/epjp/s13360-023-03866-w
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author Awasthi, Arti
author_facet Awasthi, Arti
author_sort Awasthi, Arti
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description In this paper, a mathematical model of COVID-19 has been proposed to study the transmission dynamics of infection by taking into account the role of symptomatic and asymptomatic infected individuals. The model has also considered the effect of non-pharmaceutical interventions (NPIs) in controlling the spread of virus. The basic reproduction number ([Formula: see text] ) has been computed and the analysis shows that for [Formula: see text] , the disease-free state becomes globally stable. The conditions of existence and stability for two other equilibrium states have been obtained. Transcritical bifurcation occurs when basic reproduction number is one (i.e. [Formula: see text] ). It is found that when asymptomatic cases get increased, infection will persist in the population. However, when symptomatic cases get increased as compared to asymptomatic ones, the endemic state will become unstable and infection may eradicate from the population. Increasing NPIs decrease the basic reproduction number and hence, the epidemic can be controlled. As the COVID-19 transmission is subject to environmental fluctuations, the effect of white noise has been considered in the deterministic model. The stochastic differential equation model has been solved numerically by using the Euler-Maruyama method. The stochastic model gives large fluctuations around the respective deterministic solutions. The model has been fitted by using the COVID-19 data of three waves of India. A good match is obtained between the actual data and the predicted trajectories of the model in all three waves of COVID-19. The findings of this model may assist policymakers and healthcare professionals in implementing the most effective measures to prevent the transmission of COVID-19 in different settings.
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spelling pubmed-100421142023-03-28 A mathematical model for transmission dynamics of COVID-19 infection Awasthi, Arti Eur Phys J Plus Regular Article In this paper, a mathematical model of COVID-19 has been proposed to study the transmission dynamics of infection by taking into account the role of symptomatic and asymptomatic infected individuals. The model has also considered the effect of non-pharmaceutical interventions (NPIs) in controlling the spread of virus. The basic reproduction number ([Formula: see text] ) has been computed and the analysis shows that for [Formula: see text] , the disease-free state becomes globally stable. The conditions of existence and stability for two other equilibrium states have been obtained. Transcritical bifurcation occurs when basic reproduction number is one (i.e. [Formula: see text] ). It is found that when asymptomatic cases get increased, infection will persist in the population. However, when symptomatic cases get increased as compared to asymptomatic ones, the endemic state will become unstable and infection may eradicate from the population. Increasing NPIs decrease the basic reproduction number and hence, the epidemic can be controlled. As the COVID-19 transmission is subject to environmental fluctuations, the effect of white noise has been considered in the deterministic model. The stochastic differential equation model has been solved numerically by using the Euler-Maruyama method. The stochastic model gives large fluctuations around the respective deterministic solutions. The model has been fitted by using the COVID-19 data of three waves of India. A good match is obtained between the actual data and the predicted trajectories of the model in all three waves of COVID-19. The findings of this model may assist policymakers and healthcare professionals in implementing the most effective measures to prevent the transmission of COVID-19 in different settings. Springer Berlin Heidelberg 2023-03-27 2023 /pmc/articles/PMC10042114/ /pubmed/37008754 http://dx.doi.org/10.1140/epjp/s13360-023-03866-w Text en © The Author(s), under exclusive licence to Società Italiana di Fisica and Springer-Verlag GmbH Germany, part of Springer Nature 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Regular Article
Awasthi, Arti
A mathematical model for transmission dynamics of COVID-19 infection
title A mathematical model for transmission dynamics of COVID-19 infection
title_full A mathematical model for transmission dynamics of COVID-19 infection
title_fullStr A mathematical model for transmission dynamics of COVID-19 infection
title_full_unstemmed A mathematical model for transmission dynamics of COVID-19 infection
title_short A mathematical model for transmission dynamics of COVID-19 infection
title_sort mathematical model for transmission dynamics of covid-19 infection
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042114/
https://www.ncbi.nlm.nih.gov/pubmed/37008754
http://dx.doi.org/10.1140/epjp/s13360-023-03866-w
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