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Network Pharmacology and Experimental Validation to Explore That Celastrol Targeting PTEN is the Potential Mechanism of Tripterygium wilfordii (Lév.) Hutch Against IgA Nephropathy

PURPOSE: Accumulating clinical evidence showed that Tripterygium hypoglaucum (Lév.) Hutch (THH) is effective against IgA nephropathy (IgAN), but the mechanism is still unclear. This study is to evaluate the renal protective effect and molecular mechanism of THH against IgAN via network pharmacology,...

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Detalles Bibliográficos
Autores principales:	Zhao, Juanyong, Liu, Haiyang, Xia, Ming, Chen, Qian, Wan, Lili, Leng, Bin, Tang, Chengyuan, Chen, Guochun, Liu, Yu, Zhang, Lei, Liu, Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2023
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042171/ https://www.ncbi.nlm.nih.gov/pubmed/36992900 http://dx.doi.org/10.2147/DDDT.S402503

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