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Brain endothelial cells exposure to malaria parasites links type I interferon signalling to antigen presentation, immunoproteasome activation, endothelium disruption, and cellular metabolism

INTRODUCTION: Cerebral malaria (CM) lethality is attributable to induction of brain edema induction but the cellular mechanisms involving brain microvascular endothelium in CM pathogenesis are unexplored. RESULTS: Activation of the STING-INFb-CXCL10 axis in brain endothelial cells (BECs) is a promin...

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Detalles Bibliográficos
Autores principales:	Shafi, Abdul Muktadir, Végvári, Ákos, Zubarev, Roman A., Penha-Gonçalves, Carlos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042232/ https://www.ncbi.nlm.nih.gov/pubmed/36993973 http://dx.doi.org/10.3389/fimmu.2023.1149107

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