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Prognostic value of pretreatment (18)F-FDG PET/CT metabolic parameters in esophageal high-grade neuroendocrine carcinoma: A bicenter retrospective study
OBJECTIVE: The aim of this bicentric retrospective study was to assess the prognostic value of (18)F-FDG PET/CT in patients with esophageal high-grade neuroendocrine carcinoma (NECs). METHODS: From the database of two centers, 28 patients affected by esophageal high-grade NECs who underwent (18)F-FD...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042323/ https://www.ncbi.nlm.nih.gov/pubmed/36994200 http://dx.doi.org/10.3389/fonc.2023.1145557 |
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author | Hou, Guozhu Zhao, Ningning Li, Fang Jing, Hongli Zheng, Rong |
author_facet | Hou, Guozhu Zhao, Ningning Li, Fang Jing, Hongli Zheng, Rong |
author_sort | Hou, Guozhu |
collection | PubMed |
description | OBJECTIVE: The aim of this bicentric retrospective study was to assess the prognostic value of (18)F-FDG PET/CT in patients with esophageal high-grade neuroendocrine carcinoma (NECs). METHODS: From the database of two centers, 28 patients affected by esophageal high-grade NECs who underwent (18)F-FDG PET/CT before treatment were retrospectively reviewed. Metabolic parameters (SUVmax, SUVmean, tumor-to-blood-pool SUV ratio (TBR), tumor-to-liver SUV ratio (TLR), metabolic tumor volume (MTV), total lesion glycolysis (TLG)) of the primary tumor were measured. Univariate and multivariate analyses were performed for progression-free survival (PFS) and overall survival (OS). RESULTS: After a median follow-up period of 22 months, disease progression occurred in 11 (39.3%) patients, and death occurred in 8 (28.6%) patients. The median PFS was 34 months, and the median OS was not reached. Univariate analyses revealed that among metabolic parameters, only MTV and TLG were significant prognostic factors, while among clinical variables, only distant metastasis was a significant factor for both PFS and OS (P< 0.05). On multivariate analyses, MTV and TLG were independent prognostic factors for both PFS and OS (P< 0.05). CONCLUSIONS: In patients with esophageal high-grade NEC, MTV and TLG measured on pretreatment (18)F-FDG PET/CT are independently prognostic factors for predicting PFS and OS, and might be used as quantitative prognostic imaging biomarkers. |
format | Online Article Text |
id | pubmed-10042323 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100423232023-03-28 Prognostic value of pretreatment (18)F-FDG PET/CT metabolic parameters in esophageal high-grade neuroendocrine carcinoma: A bicenter retrospective study Hou, Guozhu Zhao, Ningning Li, Fang Jing, Hongli Zheng, Rong Front Oncol Oncology OBJECTIVE: The aim of this bicentric retrospective study was to assess the prognostic value of (18)F-FDG PET/CT in patients with esophageal high-grade neuroendocrine carcinoma (NECs). METHODS: From the database of two centers, 28 patients affected by esophageal high-grade NECs who underwent (18)F-FDG PET/CT before treatment were retrospectively reviewed. Metabolic parameters (SUVmax, SUVmean, tumor-to-blood-pool SUV ratio (TBR), tumor-to-liver SUV ratio (TLR), metabolic tumor volume (MTV), total lesion glycolysis (TLG)) of the primary tumor were measured. Univariate and multivariate analyses were performed for progression-free survival (PFS) and overall survival (OS). RESULTS: After a median follow-up period of 22 months, disease progression occurred in 11 (39.3%) patients, and death occurred in 8 (28.6%) patients. The median PFS was 34 months, and the median OS was not reached. Univariate analyses revealed that among metabolic parameters, only MTV and TLG were significant prognostic factors, while among clinical variables, only distant metastasis was a significant factor for both PFS and OS (P< 0.05). On multivariate analyses, MTV and TLG were independent prognostic factors for both PFS and OS (P< 0.05). CONCLUSIONS: In patients with esophageal high-grade NEC, MTV and TLG measured on pretreatment (18)F-FDG PET/CT are independently prognostic factors for predicting PFS and OS, and might be used as quantitative prognostic imaging biomarkers. Frontiers Media S.A. 2023-03-13 /pmc/articles/PMC10042323/ /pubmed/36994200 http://dx.doi.org/10.3389/fonc.2023.1145557 Text en Copyright © 2023 Hou, Zhao, Li, Jing and Zheng https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Hou, Guozhu Zhao, Ningning Li, Fang Jing, Hongli Zheng, Rong Prognostic value of pretreatment (18)F-FDG PET/CT metabolic parameters in esophageal high-grade neuroendocrine carcinoma: A bicenter retrospective study |
title | Prognostic value of pretreatment (18)F-FDG PET/CT metabolic parameters in esophageal high-grade neuroendocrine carcinoma: A bicenter retrospective study |
title_full | Prognostic value of pretreatment (18)F-FDG PET/CT metabolic parameters in esophageal high-grade neuroendocrine carcinoma: A bicenter retrospective study |
title_fullStr | Prognostic value of pretreatment (18)F-FDG PET/CT metabolic parameters in esophageal high-grade neuroendocrine carcinoma: A bicenter retrospective study |
title_full_unstemmed | Prognostic value of pretreatment (18)F-FDG PET/CT metabolic parameters in esophageal high-grade neuroendocrine carcinoma: A bicenter retrospective study |
title_short | Prognostic value of pretreatment (18)F-FDG PET/CT metabolic parameters in esophageal high-grade neuroendocrine carcinoma: A bicenter retrospective study |
title_sort | prognostic value of pretreatment (18)f-fdg pet/ct metabolic parameters in esophageal high-grade neuroendocrine carcinoma: a bicenter retrospective study |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042323/ https://www.ncbi.nlm.nih.gov/pubmed/36994200 http://dx.doi.org/10.3389/fonc.2023.1145557 |
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