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Energy-harnessing problem solving of primordial life: Modeling the emergence of catalytic host-nested parasite life cycles
All life forms on earth ultimately descended from a primordial population dubbed the last universal common ancestor or LUCA via Darwinian evolution. Extant living systems share two salient functional features, a metabolism extracting and transforming energy required for survival, and an evolvable, i...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042343/ https://www.ncbi.nlm.nih.gov/pubmed/36972235 http://dx.doi.org/10.1371/journal.pone.0281661 |
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author | Conrad, Bernard Iseli, Christian Pirovino, Magnus |
author_facet | Conrad, Bernard Iseli, Christian Pirovino, Magnus |
author_sort | Conrad, Bernard |
collection | PubMed |
description | All life forms on earth ultimately descended from a primordial population dubbed the last universal common ancestor or LUCA via Darwinian evolution. Extant living systems share two salient functional features, a metabolism extracting and transforming energy required for survival, and an evolvable, informational polymer–the genome–conferring heredity. Genome replication invariably generates essential and ubiquitous genetic parasites. Here we model the energetic, replicative conditions of LUCA-like organisms and their parasites, as well as adaptive problem solving of host-parasite pairs. We show using an adapted Lotka-Volterra frame-work that three host-parasite pairs–individually a unit of a host and a parasite that is itself parasitized, therefore a nested parasite pair–are sufficient for robust and stable homeostasis, forming a life cycle. This nested parasitism model includes competition and habitat restriction. Its catalytic life cycle efficiently captures, channels and transforms energy, enabling dynamic host survival and adaptation. We propose a Malthusian fitness model for a quasispecies evolving through a host-nested parasite life cycle with two core features, rapid replacement of degenerate parasites and increasing evolutionary stability of host-nested parasite units from one to three pairs. |
format | Online Article Text |
id | pubmed-10042343 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-100423432023-03-28 Energy-harnessing problem solving of primordial life: Modeling the emergence of catalytic host-nested parasite life cycles Conrad, Bernard Iseli, Christian Pirovino, Magnus PLoS One Research Article All life forms on earth ultimately descended from a primordial population dubbed the last universal common ancestor or LUCA via Darwinian evolution. Extant living systems share two salient functional features, a metabolism extracting and transforming energy required for survival, and an evolvable, informational polymer–the genome–conferring heredity. Genome replication invariably generates essential and ubiquitous genetic parasites. Here we model the energetic, replicative conditions of LUCA-like organisms and their parasites, as well as adaptive problem solving of host-parasite pairs. We show using an adapted Lotka-Volterra frame-work that three host-parasite pairs–individually a unit of a host and a parasite that is itself parasitized, therefore a nested parasite pair–are sufficient for robust and stable homeostasis, forming a life cycle. This nested parasitism model includes competition and habitat restriction. Its catalytic life cycle efficiently captures, channels and transforms energy, enabling dynamic host survival and adaptation. We propose a Malthusian fitness model for a quasispecies evolving through a host-nested parasite life cycle with two core features, rapid replacement of degenerate parasites and increasing evolutionary stability of host-nested parasite units from one to three pairs. Public Library of Science 2023-03-27 /pmc/articles/PMC10042343/ /pubmed/36972235 http://dx.doi.org/10.1371/journal.pone.0281661 Text en © 2023 Conrad et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Conrad, Bernard Iseli, Christian Pirovino, Magnus Energy-harnessing problem solving of primordial life: Modeling the emergence of catalytic host-nested parasite life cycles |
title | Energy-harnessing problem solving of primordial life: Modeling the emergence of catalytic host-nested parasite life cycles |
title_full | Energy-harnessing problem solving of primordial life: Modeling the emergence of catalytic host-nested parasite life cycles |
title_fullStr | Energy-harnessing problem solving of primordial life: Modeling the emergence of catalytic host-nested parasite life cycles |
title_full_unstemmed | Energy-harnessing problem solving of primordial life: Modeling the emergence of catalytic host-nested parasite life cycles |
title_short | Energy-harnessing problem solving of primordial life: Modeling the emergence of catalytic host-nested parasite life cycles |
title_sort | energy-harnessing problem solving of primordial life: modeling the emergence of catalytic host-nested parasite life cycles |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042343/ https://www.ncbi.nlm.nih.gov/pubmed/36972235 http://dx.doi.org/10.1371/journal.pone.0281661 |
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