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IL-12p40 is essential but not sufficient for Francisella tularensis LVS clearance in chronically infected mice

IL-12p40 plays an important role in F. tularensis Live Vaccine Strain (LVS) clearance that is independent of its functions as a part of the heterodimeric cytokines IL-12p70 or IL-23. In contrast to WT, p35, or p19 knockout (KO) mice, p40 KO mice infected with LVS develop a chronic infection that doe...

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Detalles Bibliográficos
Autores principales:	Mittereder, Lara R., Swoboda, Jonathan, De Pascalis, Roberto, Elkins, Karen L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042368/ https://www.ncbi.nlm.nih.gov/pubmed/36972230 http://dx.doi.org/10.1371/journal.pone.0283161

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