Genetic diversity of Mycobacterium leprae in the state of São Paulo, an area of low-leprosy incidence in Brazil

BACKGROUND: Brazil has the second largest number of leprosy cases worldwide, and the state of São Paulo has been considered non-endemic since 2006. METHODS: We analyzed 16 variable number tandem repeats loci and three single nucleotide polymorphisms loci of Mycobacterium leprae (M. leprae) in 125 cl...

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Autores principales: Finardi, Amanda Juliane, de Oliveira, Nathan Guilherme, de Moraes, Eloise Brasil, Batista, Lavínia Cássia Ferreira, Bortolomai, Bruna Eduarda, Suffys, Philip Noel, Baptista, Ida Maria Foschiani Dias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Medicina Tropical - SBMT 2023
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042472/
https://www.ncbi.nlm.nih.gov/pubmed/36995787
http://dx.doi.org/10.1590/0037-8682-0612-2022
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author Finardi, Amanda Juliane
de Oliveira, Nathan Guilherme
de Moraes, Eloise Brasil
Batista, Lavínia Cássia Ferreira
Bortolomai, Bruna Eduarda
Suffys, Philip Noel
Baptista, Ida Maria Foschiani Dias
author_facet Finardi, Amanda Juliane
de Oliveira, Nathan Guilherme
de Moraes, Eloise Brasil
Batista, Lavínia Cássia Ferreira
Bortolomai, Bruna Eduarda
Suffys, Philip Noel
Baptista, Ida Maria Foschiani Dias
author_sort Finardi, Amanda Juliane
collection PubMed
description BACKGROUND: Brazil has the second largest number of leprosy cases worldwide, and the state of São Paulo has been considered non-endemic since 2006. METHODS: We analyzed 16 variable number tandem repeats loci and three single nucleotide polymorphisms loci of Mycobacterium leprae (M. leprae) in 125 clinical isolates from patients in different municipalities in the state. RESULTS: The clustering pattern of M. leprae indicated that the transmission of leprosy persisted in the state and included scenarios of intra-extra-familial transmission in areas with low endemicity. CONCLUSIONS: A significantly active circulation of M. leprae was observed. Therefore, surveillance and control measures must be implemented.
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spelling pubmed-100424722023-03-28 Genetic diversity of Mycobacterium leprae in the state of São Paulo, an area of low-leprosy incidence in Brazil Finardi, Amanda Juliane de Oliveira, Nathan Guilherme de Moraes, Eloise Brasil Batista, Lavínia Cássia Ferreira Bortolomai, Bruna Eduarda Suffys, Philip Noel Baptista, Ida Maria Foschiani Dias Rev Soc Bras Med Trop Short Communication BACKGROUND: Brazil has the second largest number of leprosy cases worldwide, and the state of São Paulo has been considered non-endemic since 2006. METHODS: We analyzed 16 variable number tandem repeats loci and three single nucleotide polymorphisms loci of Mycobacterium leprae (M. leprae) in 125 clinical isolates from patients in different municipalities in the state. RESULTS: The clustering pattern of M. leprae indicated that the transmission of leprosy persisted in the state and included scenarios of intra-extra-familial transmission in areas with low endemicity. CONCLUSIONS: A significantly active circulation of M. leprae was observed. Therefore, surveillance and control measures must be implemented. Sociedade Brasileira de Medicina Tropical - SBMT 2023-03-27 /pmc/articles/PMC10042472/ /pubmed/36995787 http://dx.doi.org/10.1590/0037-8682-0612-2022 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Short Communication
Finardi, Amanda Juliane
de Oliveira, Nathan Guilherme
de Moraes, Eloise Brasil
Batista, Lavínia Cássia Ferreira
Bortolomai, Bruna Eduarda
Suffys, Philip Noel
Baptista, Ida Maria Foschiani Dias
Genetic diversity of Mycobacterium leprae in the state of São Paulo, an area of low-leprosy incidence in Brazil
title Genetic diversity of Mycobacterium leprae in the state of São Paulo, an area of low-leprosy incidence in Brazil
title_full Genetic diversity of Mycobacterium leprae in the state of São Paulo, an area of low-leprosy incidence in Brazil
title_fullStr Genetic diversity of Mycobacterium leprae in the state of São Paulo, an area of low-leprosy incidence in Brazil
title_full_unstemmed Genetic diversity of Mycobacterium leprae in the state of São Paulo, an area of low-leprosy incidence in Brazil
title_short Genetic diversity of Mycobacterium leprae in the state of São Paulo, an area of low-leprosy incidence in Brazil
title_sort genetic diversity of mycobacterium leprae in the state of são paulo, an area of low-leprosy incidence in brazil
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042472/
https://www.ncbi.nlm.nih.gov/pubmed/36995787
http://dx.doi.org/10.1590/0037-8682-0612-2022
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