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Fasting Versus Non-Fasting Total Testosterone Levels in Women During the Childbearing Period

Background Total testosterone in men should be measured in the fasting state early in the morning with at least two samples according to guidelines. For women, no such a recommendation is available despite the importance of testosterone in this demographic. The aim of this study is to evaluate the e...

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Autores principales: Baqer Ali, Emad, Alhamza, Ali, Zaboon, Ibraheem A, Alidrisi, Haider A, Mansour, Abbas A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042517/
https://www.ncbi.nlm.nih.gov/pubmed/36994254
http://dx.doi.org/10.7759/cureus.35462
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author Baqer Ali, Emad
Alhamza, Ali
Zaboon, Ibraheem A
Alidrisi, Haider A
Mansour, Abbas A
author_facet Baqer Ali, Emad
Alhamza, Ali
Zaboon, Ibraheem A
Alidrisi, Haider A
Mansour, Abbas A
author_sort Baqer Ali, Emad
collection PubMed
description Background Total testosterone in men should be measured in the fasting state early in the morning with at least two samples according to guidelines. For women, no such a recommendation is available despite the importance of testosterone in this demographic. The aim of this study is to evaluate the effect of fasting versus non-fasting state on the total testosterone levels in women during the reproductive period. Methods This study was conducted at Faiha Specialized Diabetes, Endocrine and Metabolism Center in Basrah, (Southern Iraq) between January 2022 to November 2022. The total enrolled women were 109; their age was 18-45 years. The presentation was for different complaints; 56 presented for medical consultation with 45 apparently healthy women accompanying the patients as well as eight volunteering female doctors. Testosterone levels were measured by electrochemiluminescence immunoassays using the Roche Cobas e411 platform (Roche Holding, Basel, Switzerland). Two samples were collected from each woman; one was fasting and another was non-fasting the following day, and all samples were taken before 10 am. Results  For all of the participants, the mean ± SD fasting was significantly higher as compared to the non-fasting testosterone (27.39±18.8 ng/dL and 24.47±18.6 ng/dL respectively, p-value 0.01). The mean fasting testosterone level was also significantly higher in the apparently healthy group, (p-value 0.01). In women who presented with hirsutism, menstrual irregularities and or hair fall, no difference was seen in the testosterone levels between fasting and non-fasting states (p-value 0.4).  Conclusion In the apparently healthy women of childbearing age, serum testosterone levels were higher in the fasting versus the non-fasting states. In women who presented with complaints of hirsutism, menstrual irregularities, and or hair fall, the serum testosterone levels were not affected by the fasting states.
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spelling pubmed-100425172023-03-28 Fasting Versus Non-Fasting Total Testosterone Levels in Women During the Childbearing Period Baqer Ali, Emad Alhamza, Ali Zaboon, Ibraheem A Alidrisi, Haider A Mansour, Abbas A Cureus Endocrinology/Diabetes/Metabolism Background Total testosterone in men should be measured in the fasting state early in the morning with at least two samples according to guidelines. For women, no such a recommendation is available despite the importance of testosterone in this demographic. The aim of this study is to evaluate the effect of fasting versus non-fasting state on the total testosterone levels in women during the reproductive period. Methods This study was conducted at Faiha Specialized Diabetes, Endocrine and Metabolism Center in Basrah, (Southern Iraq) between January 2022 to November 2022. The total enrolled women were 109; their age was 18-45 years. The presentation was for different complaints; 56 presented for medical consultation with 45 apparently healthy women accompanying the patients as well as eight volunteering female doctors. Testosterone levels were measured by electrochemiluminescence immunoassays using the Roche Cobas e411 platform (Roche Holding, Basel, Switzerland). Two samples were collected from each woman; one was fasting and another was non-fasting the following day, and all samples were taken before 10 am. Results  For all of the participants, the mean ± SD fasting was significantly higher as compared to the non-fasting testosterone (27.39±18.8 ng/dL and 24.47±18.6 ng/dL respectively, p-value 0.01). The mean fasting testosterone level was also significantly higher in the apparently healthy group, (p-value 0.01). In women who presented with hirsutism, menstrual irregularities and or hair fall, no difference was seen in the testosterone levels between fasting and non-fasting states (p-value 0.4).  Conclusion In the apparently healthy women of childbearing age, serum testosterone levels were higher in the fasting versus the non-fasting states. In women who presented with complaints of hirsutism, menstrual irregularities, and or hair fall, the serum testosterone levels were not affected by the fasting states. Cureus 2023-02-25 /pmc/articles/PMC10042517/ /pubmed/36994254 http://dx.doi.org/10.7759/cureus.35462 Text en Copyright © 2023, Baqer Ali et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Endocrinology/Diabetes/Metabolism
Baqer Ali, Emad
Alhamza, Ali
Zaboon, Ibraheem A
Alidrisi, Haider A
Mansour, Abbas A
Fasting Versus Non-Fasting Total Testosterone Levels in Women During the Childbearing Period
title Fasting Versus Non-Fasting Total Testosterone Levels in Women During the Childbearing Period
title_full Fasting Versus Non-Fasting Total Testosterone Levels in Women During the Childbearing Period
title_fullStr Fasting Versus Non-Fasting Total Testosterone Levels in Women During the Childbearing Period
title_full_unstemmed Fasting Versus Non-Fasting Total Testosterone Levels in Women During the Childbearing Period
title_short Fasting Versus Non-Fasting Total Testosterone Levels in Women During the Childbearing Period
title_sort fasting versus non-fasting total testosterone levels in women during the childbearing period
topic Endocrinology/Diabetes/Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042517/
https://www.ncbi.nlm.nih.gov/pubmed/36994254
http://dx.doi.org/10.7759/cureus.35462
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