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BK-Virus-Induced Hemorrhagic Cystitis in a Patient With Graft-Versus-Host Disease

The BK virus is a polyomavirus known to particularly affect transplant recipients. An important complication caused by BK virus infection in bone marrow transplant patients is hemorrhagic cystitis. We present a 31-year-old male with a history of bone marrow transplantation complicated by graft-versu...

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Autores principales: Mohamed Jiffry, Mohamed Zakee, Rangsipat, Napat, Tabares, Daniel, Khan, Aimal, Thomas, Teena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042525/
https://www.ncbi.nlm.nih.gov/pubmed/36994296
http://dx.doi.org/10.7759/cureus.35413
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author Mohamed Jiffry, Mohamed Zakee
Rangsipat, Napat
Tabares, Daniel
Khan, Aimal
Thomas, Teena
author_facet Mohamed Jiffry, Mohamed Zakee
Rangsipat, Napat
Tabares, Daniel
Khan, Aimal
Thomas, Teena
author_sort Mohamed Jiffry, Mohamed Zakee
collection PubMed
description The BK virus is a polyomavirus known to particularly affect transplant recipients. An important complication caused by BK virus infection in bone marrow transplant patients is hemorrhagic cystitis. We present a 31-year-old male with a history of bone marrow transplantation complicated by graft-versus-host disease (GVHD) and was diagnosed with BK virus-related hemorrhagic cystitis. He presented with gross hematuria and suprapubic and penile pain for one week. He has a significant past medical history of acute B-cell lymphocytic leukemia for which he has successfully undergone allogenic bone marrow transplantation, which was complicated by GVHD. Imaging revealed significant bladder wall thickening which prompted an evaluation for BK virus-induced hemorrhagic cystitis. A urinary specimen was sent for BK virus polymerase chain reaction (PCR) which was strongly positive, confirming the infection. He was managed supportively throughout his hospitalization and improved with symptomatic management alone. Our case demonstrates one of the main complications caused by the BK virus in allogeneic bone marrow transplant patients in the setting of GVHD and is an important differential to keep in mind when treating patients presenting with hematuria after bone marrow transplantation.
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spelling pubmed-100425252023-03-28 BK-Virus-Induced Hemorrhagic Cystitis in a Patient With Graft-Versus-Host Disease Mohamed Jiffry, Mohamed Zakee Rangsipat, Napat Tabares, Daniel Khan, Aimal Thomas, Teena Cureus Infectious Disease The BK virus is a polyomavirus known to particularly affect transplant recipients. An important complication caused by BK virus infection in bone marrow transplant patients is hemorrhagic cystitis. We present a 31-year-old male with a history of bone marrow transplantation complicated by graft-versus-host disease (GVHD) and was diagnosed with BK virus-related hemorrhagic cystitis. He presented with gross hematuria and suprapubic and penile pain for one week. He has a significant past medical history of acute B-cell lymphocytic leukemia for which he has successfully undergone allogenic bone marrow transplantation, which was complicated by GVHD. Imaging revealed significant bladder wall thickening which prompted an evaluation for BK virus-induced hemorrhagic cystitis. A urinary specimen was sent for BK virus polymerase chain reaction (PCR) which was strongly positive, confirming the infection. He was managed supportively throughout his hospitalization and improved with symptomatic management alone. Our case demonstrates one of the main complications caused by the BK virus in allogeneic bone marrow transplant patients in the setting of GVHD and is an important differential to keep in mind when treating patients presenting with hematuria after bone marrow transplantation. Cureus 2023-02-24 /pmc/articles/PMC10042525/ /pubmed/36994296 http://dx.doi.org/10.7759/cureus.35413 Text en Copyright © 2023, Mohamed Jiffry et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Infectious Disease
Mohamed Jiffry, Mohamed Zakee
Rangsipat, Napat
Tabares, Daniel
Khan, Aimal
Thomas, Teena
BK-Virus-Induced Hemorrhagic Cystitis in a Patient With Graft-Versus-Host Disease
title BK-Virus-Induced Hemorrhagic Cystitis in a Patient With Graft-Versus-Host Disease
title_full BK-Virus-Induced Hemorrhagic Cystitis in a Patient With Graft-Versus-Host Disease
title_fullStr BK-Virus-Induced Hemorrhagic Cystitis in a Patient With Graft-Versus-Host Disease
title_full_unstemmed BK-Virus-Induced Hemorrhagic Cystitis in a Patient With Graft-Versus-Host Disease
title_short BK-Virus-Induced Hemorrhagic Cystitis in a Patient With Graft-Versus-Host Disease
title_sort bk-virus-induced hemorrhagic cystitis in a patient with graft-versus-host disease
topic Infectious Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042525/
https://www.ncbi.nlm.nih.gov/pubmed/36994296
http://dx.doi.org/10.7759/cureus.35413
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