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Chronic Kidney Disease of Unknown Etiology in a Tertiary Care Teaching Hospital

Background Several primary studies have looked at the burden of chronic kidney disease among diabetic patients, but their results have shown significant variance in India. In order to determine the combined prevalence of chronic kidney disease and associated risk factors among patients with diabetes...

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Autores principales: Mughni, Mohammed A, Mateen, Mohammed A, Asifuddin, Mohammed, Khan, Khaja K, Khan, Ariyan, Khan, Maria, Prajjwal, Priyadarshi, Ranjan, Raunak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042529/
https://www.ncbi.nlm.nih.gov/pubmed/36994299
http://dx.doi.org/10.7759/cureus.35446
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author Mughni, Mohammed A
Mateen, Mohammed A
Asifuddin, Mohammed
Khan, Khaja K
Khan, Ariyan
Khan, Maria
Prajjwal, Priyadarshi
Ranjan, Raunak
author_facet Mughni, Mohammed A
Mateen, Mohammed A
Asifuddin, Mohammed
Khan, Khaja K
Khan, Ariyan
Khan, Maria
Prajjwal, Priyadarshi
Ranjan, Raunak
author_sort Mughni, Mohammed A
collection PubMed
description Background Several primary studies have looked at the burden of chronic kidney disease among diabetic patients, but their results have shown significant variance in India. In order to determine the combined prevalence of chronic kidney disease and associated risk factors among patients with diabetes, this study used a combination of methods. Methods Over the course of two years, a cross-sectional observational study was undertaken in the Tertiary Care Teaching Hospital's Department of General Medicine including all chronic kidney disease patients of 18 years of age and above of either gender. People not suffering from the disease were chosen as controls. Kidney Injury Molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin-ELISA (NGAL-ELISA) sample analysis by the kit method was done. The study was carried out in accordance with Schedule Y, ICH GCP principles, and the Helsinki Declaration after receiving approval from the institutional ethics committee. Results In our study, the urinary mean KIM-1 was 49.75±4.35 μg/g Cr in the Chronic Kidney Disease of Unknown etiology (CKDu) group and 1.43±0.15 μg/g Cr in the controls group. The mean NGAL levels of the CKDu Group and the controls group were 8.94±1.31 μg/g and 0.41±0.05 μg/g, respectively. In CKDu and the controls group, the mean eGFR (ml/min/1.73m(2)) was 69.83±7.91 and 108±3.7, respectively. The mean serum creatinine (mg/dL) was reported 3.79 in the CKDu group and 1.0 in the controls group. Conclusion Despite the urban centers previously being thought of as a non-endemic location, for the first time in the city, 60 CKDu patients are reported in this study. This is the first study to use the urinary biomarkers KIM-1 and NGAL to find suspected cases of CKDu and early kidney damage in local communities in the urban centers.
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spelling pubmed-100425292023-03-28 Chronic Kidney Disease of Unknown Etiology in a Tertiary Care Teaching Hospital Mughni, Mohammed A Mateen, Mohammed A Asifuddin, Mohammed Khan, Khaja K Khan, Ariyan Khan, Maria Prajjwal, Priyadarshi Ranjan, Raunak Cureus Internal Medicine Background Several primary studies have looked at the burden of chronic kidney disease among diabetic patients, but their results have shown significant variance in India. In order to determine the combined prevalence of chronic kidney disease and associated risk factors among patients with diabetes, this study used a combination of methods. Methods Over the course of two years, a cross-sectional observational study was undertaken in the Tertiary Care Teaching Hospital's Department of General Medicine including all chronic kidney disease patients of 18 years of age and above of either gender. People not suffering from the disease were chosen as controls. Kidney Injury Molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin-ELISA (NGAL-ELISA) sample analysis by the kit method was done. The study was carried out in accordance with Schedule Y, ICH GCP principles, and the Helsinki Declaration after receiving approval from the institutional ethics committee. Results In our study, the urinary mean KIM-1 was 49.75±4.35 μg/g Cr in the Chronic Kidney Disease of Unknown etiology (CKDu) group and 1.43±0.15 μg/g Cr in the controls group. The mean NGAL levels of the CKDu Group and the controls group were 8.94±1.31 μg/g and 0.41±0.05 μg/g, respectively. In CKDu and the controls group, the mean eGFR (ml/min/1.73m(2)) was 69.83±7.91 and 108±3.7, respectively. The mean serum creatinine (mg/dL) was reported 3.79 in the CKDu group and 1.0 in the controls group. Conclusion Despite the urban centers previously being thought of as a non-endemic location, for the first time in the city, 60 CKDu patients are reported in this study. This is the first study to use the urinary biomarkers KIM-1 and NGAL to find suspected cases of CKDu and early kidney damage in local communities in the urban centers. Cureus 2023-02-25 /pmc/articles/PMC10042529/ /pubmed/36994299 http://dx.doi.org/10.7759/cureus.35446 Text en Copyright © 2023, Mughni et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Mughni, Mohammed A
Mateen, Mohammed A
Asifuddin, Mohammed
Khan, Khaja K
Khan, Ariyan
Khan, Maria
Prajjwal, Priyadarshi
Ranjan, Raunak
Chronic Kidney Disease of Unknown Etiology in a Tertiary Care Teaching Hospital
title Chronic Kidney Disease of Unknown Etiology in a Tertiary Care Teaching Hospital
title_full Chronic Kidney Disease of Unknown Etiology in a Tertiary Care Teaching Hospital
title_fullStr Chronic Kidney Disease of Unknown Etiology in a Tertiary Care Teaching Hospital
title_full_unstemmed Chronic Kidney Disease of Unknown Etiology in a Tertiary Care Teaching Hospital
title_short Chronic Kidney Disease of Unknown Etiology in a Tertiary Care Teaching Hospital
title_sort chronic kidney disease of unknown etiology in a tertiary care teaching hospital
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042529/
https://www.ncbi.nlm.nih.gov/pubmed/36994299
http://dx.doi.org/10.7759/cureus.35446
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