Disrupting the phase separation of KAT8–IRF1 diminishes PD-L1 expression and promotes antitumor immunity

Immunotherapies targeting the PD-1/PD-L1 axis have become first-line treatments in multiple cancers. However, only a limited subset of individuals achieves durable benefits because of the elusive mechanisms regulating PD-1/PD-L1. Here, we report that in cells exposed to interferon-γ (IFNγ), KAT8 und...

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Detalles Bibliográficos
Autores principales: Wu, Yuanzhong, Zhou, Liwen, Zou, Yezi, Zhang, Yijun, Zhang, Meifang, Xu, Liping, Zheng, Lisi, He, Wenting, Yu, Kuai, Li, Ting, Zhang, Xia, Chen, Zhenxuan, Zhang, Ruhua, Zhou, Penghui, Zhang, Nu, Zheng, Limin, Kang, Tiebang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042735/
https://www.ncbi.nlm.nih.gov/pubmed/36894639
http://dx.doi.org/10.1038/s43018-023-00522-1

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