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Metabolically healthy and unhealthy obesity and the development of lung dysfunction
We investigated the association of metabolically healthy (MH) and unhealthy (MU) obesity with incident lung dysfunction. This cohort study included 253,698 Korean lung disease-free adults (mean age, 37.4 years) at baseline. Spirometry-defined lung dysfunction was classified as a restrictive pattern...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042802/ https://www.ncbi.nlm.nih.gov/pubmed/36973389 http://dx.doi.org/10.1038/s41598-023-31960-7 |
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author | Song, Jae-Uk Lee, Jonghoo Lim, Si-Young Gil, Hyun-Il Chang, Yoosoo Ryu, Seungho |
author_facet | Song, Jae-Uk Lee, Jonghoo Lim, Si-Young Gil, Hyun-Il Chang, Yoosoo Ryu, Seungho |
author_sort | Song, Jae-Uk |
collection | PubMed |
description | We investigated the association of metabolically healthy (MH) and unhealthy (MU) obesity with incident lung dysfunction. This cohort study included 253,698 Korean lung disease-free adults (mean age, 37.4 years) at baseline. Spirometry-defined lung dysfunction was classified as a restrictive pattern (RP) or obstructive pattern (OP). We defined obesity as BMI ≥ 25 kg/m(2) and MH as the absence of any metabolic syndrome components with a homeostasis model assessment of insulin resistance < 2.5: otherwise, participants were considered MU. During a median follow-up of 4.9 years, 10,775 RP cases and 7140 OP cases develped. Both MH and MU obesity showed a positive association with incident RP, with a stronger association in the MU than in the MH group (P(interaction) = 0.001). Multivariable-adjusted hazard ratios (95% CI) for incident RP comparing obesity to the normal-weight category was 1.15 (1.05–1.25) among the MH group and 1.38 (1.30–1.47) among MU group. Conversely, obesity was inversely associated with OP because of a greater decline in forced vital capacity than forced expiratory volume in 1 s. Both MH and MU obesity were positively associated with RP. However, the associations between obesity, metabolic health, and lung functions might vary depending on the type of lung disease. |
format | Online Article Text |
id | pubmed-10042802 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-100428022023-03-29 Metabolically healthy and unhealthy obesity and the development of lung dysfunction Song, Jae-Uk Lee, Jonghoo Lim, Si-Young Gil, Hyun-Il Chang, Yoosoo Ryu, Seungho Sci Rep Article We investigated the association of metabolically healthy (MH) and unhealthy (MU) obesity with incident lung dysfunction. This cohort study included 253,698 Korean lung disease-free adults (mean age, 37.4 years) at baseline. Spirometry-defined lung dysfunction was classified as a restrictive pattern (RP) or obstructive pattern (OP). We defined obesity as BMI ≥ 25 kg/m(2) and MH as the absence of any metabolic syndrome components with a homeostasis model assessment of insulin resistance < 2.5: otherwise, participants were considered MU. During a median follow-up of 4.9 years, 10,775 RP cases and 7140 OP cases develped. Both MH and MU obesity showed a positive association with incident RP, with a stronger association in the MU than in the MH group (P(interaction) = 0.001). Multivariable-adjusted hazard ratios (95% CI) for incident RP comparing obesity to the normal-weight category was 1.15 (1.05–1.25) among the MH group and 1.38 (1.30–1.47) among MU group. Conversely, obesity was inversely associated with OP because of a greater decline in forced vital capacity than forced expiratory volume in 1 s. Both MH and MU obesity were positively associated with RP. However, the associations between obesity, metabolic health, and lung functions might vary depending on the type of lung disease. Nature Publishing Group UK 2023-03-27 /pmc/articles/PMC10042802/ /pubmed/36973389 http://dx.doi.org/10.1038/s41598-023-31960-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Song, Jae-Uk Lee, Jonghoo Lim, Si-Young Gil, Hyun-Il Chang, Yoosoo Ryu, Seungho Metabolically healthy and unhealthy obesity and the development of lung dysfunction |
title | Metabolically healthy and unhealthy obesity and the development of lung dysfunction |
title_full | Metabolically healthy and unhealthy obesity and the development of lung dysfunction |
title_fullStr | Metabolically healthy and unhealthy obesity and the development of lung dysfunction |
title_full_unstemmed | Metabolically healthy and unhealthy obesity and the development of lung dysfunction |
title_short | Metabolically healthy and unhealthy obesity and the development of lung dysfunction |
title_sort | metabolically healthy and unhealthy obesity and the development of lung dysfunction |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042802/ https://www.ncbi.nlm.nih.gov/pubmed/36973389 http://dx.doi.org/10.1038/s41598-023-31960-7 |
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