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Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders

Hypusination is a unique post-translational modification of the eukaryotic translation factor 5A (eIF5A) that is essential for overcoming ribosome stalling at polyproline sequence stretches. The initial step of hypusination, the formation of deoxyhypusine, is catalyzed by deoxyhypusine synthase (DHS...

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Detalles Bibliográficos
Autores principales:	Wątor, Elżbieta, Wilk, Piotr, Biela, Artur, Rawski, Michał, Zak, Krzysztof M., Steinchen, Wieland, Bange, Gert, Glatt, Sebastian, Grudnik, Przemysław
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042821/ https://www.ncbi.nlm.nih.gov/pubmed/36973244 http://dx.doi.org/10.1038/s41467-023-37305-2

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