Cargando…

Magnetothermal-based non-invasive focused magnetic stimulation for functional recovery in chronic stroke treatment

Magnetic heat-based brain stimulation of specific lesions could promote the restoration of impaired motor function caused by chronic stroke. We delivered localized stimulation by nanoparticle-mediated heat generation within the targeted brain area via focused magnetic stimulation. The middle cerebra...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Hohyeon, Kim, Jihye, Kim, Jahae, Oh, Seungjun, Choi, Kangho, Yoon, Jungwon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042827/
https://www.ncbi.nlm.nih.gov/pubmed/36973390
http://dx.doi.org/10.1038/s41598-023-31979-w
_version_ 1784913017456033792
author Kim, Hohyeon
Kim, Jihye
Kim, Jahae
Oh, Seungjun
Choi, Kangho
Yoon, Jungwon
author_facet Kim, Hohyeon
Kim, Jihye
Kim, Jahae
Oh, Seungjun
Choi, Kangho
Yoon, Jungwon
author_sort Kim, Hohyeon
collection PubMed
description Magnetic heat-based brain stimulation of specific lesions could promote the restoration of impaired motor function caused by chronic stroke. We delivered localized stimulation by nanoparticle-mediated heat generation within the targeted brain area via focused magnetic stimulation. The middle cerebral artery occlusion model was prepared, and functional recovery in the chronic-phase stroke rat model was demonstrated by the therapeutic application of focused magnetic stimulation. We observed a transient increase in blood–brain barrier permeability at the target site of < 4 mm and metabolic brain activation at the target lesion. After focused magnetic stimulation, the rotarod score increased by 390 ± 28% (p < 0.05) compared to the control group. Standardized uptake value in the focused magnetic stimulation group increased by 2063 ± 748% (p < 0.01) compared to the control group. Moreover, an increase by 24 ± 5% (p < 0.05) was observed in the sham group as well. Our results show that non-invasive focused magnetic stimulation can safely modulate BBB permeability and enhance neural activation for chronic-phase stroke treatment in the targeted deep brain area.
format Online
Article
Text
id pubmed-10042827
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-100428272023-03-29 Magnetothermal-based non-invasive focused magnetic stimulation for functional recovery in chronic stroke treatment Kim, Hohyeon Kim, Jihye Kim, Jahae Oh, Seungjun Choi, Kangho Yoon, Jungwon Sci Rep Article Magnetic heat-based brain stimulation of specific lesions could promote the restoration of impaired motor function caused by chronic stroke. We delivered localized stimulation by nanoparticle-mediated heat generation within the targeted brain area via focused magnetic stimulation. The middle cerebral artery occlusion model was prepared, and functional recovery in the chronic-phase stroke rat model was demonstrated by the therapeutic application of focused magnetic stimulation. We observed a transient increase in blood–brain barrier permeability at the target site of < 4 mm and metabolic brain activation at the target lesion. After focused magnetic stimulation, the rotarod score increased by 390 ± 28% (p < 0.05) compared to the control group. Standardized uptake value in the focused magnetic stimulation group increased by 2063 ± 748% (p < 0.01) compared to the control group. Moreover, an increase by 24 ± 5% (p < 0.05) was observed in the sham group as well. Our results show that non-invasive focused magnetic stimulation can safely modulate BBB permeability and enhance neural activation for chronic-phase stroke treatment in the targeted deep brain area. Nature Publishing Group UK 2023-03-27 /pmc/articles/PMC10042827/ /pubmed/36973390 http://dx.doi.org/10.1038/s41598-023-31979-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kim, Hohyeon
Kim, Jihye
Kim, Jahae
Oh, Seungjun
Choi, Kangho
Yoon, Jungwon
Magnetothermal-based non-invasive focused magnetic stimulation for functional recovery in chronic stroke treatment
title Magnetothermal-based non-invasive focused magnetic stimulation for functional recovery in chronic stroke treatment
title_full Magnetothermal-based non-invasive focused magnetic stimulation for functional recovery in chronic stroke treatment
title_fullStr Magnetothermal-based non-invasive focused magnetic stimulation for functional recovery in chronic stroke treatment
title_full_unstemmed Magnetothermal-based non-invasive focused magnetic stimulation for functional recovery in chronic stroke treatment
title_short Magnetothermal-based non-invasive focused magnetic stimulation for functional recovery in chronic stroke treatment
title_sort magnetothermal-based non-invasive focused magnetic stimulation for functional recovery in chronic stroke treatment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042827/
https://www.ncbi.nlm.nih.gov/pubmed/36973390
http://dx.doi.org/10.1038/s41598-023-31979-w
work_keys_str_mv AT kimhohyeon magnetothermalbasednoninvasivefocusedmagneticstimulationforfunctionalrecoveryinchronicstroketreatment
AT kimjihye magnetothermalbasednoninvasivefocusedmagneticstimulationforfunctionalrecoveryinchronicstroketreatment
AT kimjahae magnetothermalbasednoninvasivefocusedmagneticstimulationforfunctionalrecoveryinchronicstroketreatment
AT ohseungjun magnetothermalbasednoninvasivefocusedmagneticstimulationforfunctionalrecoveryinchronicstroketreatment
AT choikangho magnetothermalbasednoninvasivefocusedmagneticstimulationforfunctionalrecoveryinchronicstroketreatment
AT yoonjungwon magnetothermalbasednoninvasivefocusedmagneticstimulationforfunctionalrecoveryinchronicstroketreatment