Epigenetic and transcriptomic characterization reveals progression markers and essential pathways in clear cell renal cell carcinoma

Identifying tumor-cell-specific markers and elucidating their epigenetic regulation and spatial heterogeneity provides mechanistic insights into cancer etiology. Here, we perform snRNA-seq and snATAC-seq in 34 and 28 human clear cell renal cell carcinoma (ccRCC) specimens, respectively, with matched...

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Detalles Bibliográficos
Autores principales: Wu, Yige, Terekhanova, Nadezhda V., Caravan, Wagma, Naser Al Deen, Nataly, Lal, Preet, Chen, Siqi, Mo, Chia-Kuei, Cao, Song, Li, Yize, Karpova, Alla, Liu, Ruiyang, Zhao, Yanyan, Shinkle, Andrew, Strunilin, Ilya, Weimholt, Cody, Sato, Kazuhito, Yao, Lijun, Serasanambati, Mamatha, Yang, Xiaolu, Wyczalkowski, Matthew, Zhu, Houxiang, Zhou, Daniel Cui, Jayasinghe, Reyka G., Mendez, Daniel, Wendl, Michael C., Clark, David, Newton, Chelsea, Ruan, Yijun, Reimers, Melissa A., Pachynski, Russell K., Kinsinger, Chris, Jewell, Scott, Chan, Daniel W., Zhang, Hui, Chaudhuri, Aadel A., Chheda, Milan G., Humphreys, Benjamin D., Mesri, Mehdi, Rodriguez, Henry, Hsieh, James J., Ding, Li, Chen, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042888/
https://www.ncbi.nlm.nih.gov/pubmed/36973268
http://dx.doi.org/10.1038/s41467-023-37211-7

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