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Verapamil inhibits Kir2.3 channels by binding to the pore and interfering with PIP(2) binding

The inwardly rectifying potassium current of the cardiomyocyte (I(K1)) is the main determinant of the resting potential. Ion channels Kir2.1, Kir2.2, and Kir2.3 form tetramers and are the molecular correlate of macroscopic I(K1) current. Verapamil is an antiarrhythmic drug used to suppress atrial an...

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Detalles Bibliográficos
Autores principales:	Xynogalos, Panagiotis, Rahm, Ann-Kathrin, Fried, Sebastian, Chasan, Safak, Scherer, Daniel, Seyler, Claudia, Katus, Hugo A., Frey, Norbert, Zitron, Edgar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042922/ https://www.ncbi.nlm.nih.gov/pubmed/36445385 http://dx.doi.org/10.1007/s00210-022-02342-z

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