Sirt1 regulates microglial activation and inflammation following oxygen-glucose deprivation/reoxygenation injury by targeting the Shh/Gli-1 signaling pathway

BACKGROUND: Cerebral ischemic injury leads to over-activation of microglia, which release pro-inflammatory factors that deteriorate neurological function during the acute phase of stroke. Thus, inhibiting microglial over-activation is crucial for reducing ischemic injury. Sirtuin 1 (Sirt1) has been...

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Detalles Bibliográficos
Autores principales: Liao, Hongyan, Huang, Jiagui, Liu, Jie, Zhu, Huimin, Chen, Yue, Li, Xuemei, Wen, Jun, Yang, Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10042964/
https://www.ncbi.nlm.nih.gov/pubmed/36725745
http://dx.doi.org/10.1007/s11033-022-08167-6

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