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Immunological Markers for Central Nervous System Glia
Glial cells in the central nervous system (CNS) are composed of oligodendrocytes, astrocytes and microglia. They contribute more than half of the total cells of the CNS, and are essential for neural development and functioning. Studies on the fate specification, differentiation, and functional diver...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Nature Singapore
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043115/ https://www.ncbi.nlm.nih.gov/pubmed/36028641 http://dx.doi.org/10.1007/s12264-022-00938-2 |
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author | Huang, Hao He, Wanjun Tang, Tao Qiu, Mengsheng |
author_facet | Huang, Hao He, Wanjun Tang, Tao Qiu, Mengsheng |
author_sort | Huang, Hao |
collection | PubMed |
description | Glial cells in the central nervous system (CNS) are composed of oligodendrocytes, astrocytes and microglia. They contribute more than half of the total cells of the CNS, and are essential for neural development and functioning. Studies on the fate specification, differentiation, and functional diversification of glial cells mainly rely on the proper use of cell- or stage-specific molecular markers. However, as cellular markers often exhibit different specificity and sensitivity, careful consideration must be given prior to their application to avoid possible confusion. Here, we provide an updated overview of a list of well-established immunological markers for the labeling of central glia, and discuss the cell-type specificity and stage dependency of their expression. |
format | Online Article Text |
id | pubmed-10043115 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer Nature Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-100431152023-03-29 Immunological Markers for Central Nervous System Glia Huang, Hao He, Wanjun Tang, Tao Qiu, Mengsheng Neurosci Bull Review Glial cells in the central nervous system (CNS) are composed of oligodendrocytes, astrocytes and microglia. They contribute more than half of the total cells of the CNS, and are essential for neural development and functioning. Studies on the fate specification, differentiation, and functional diversification of glial cells mainly rely on the proper use of cell- or stage-specific molecular markers. However, as cellular markers often exhibit different specificity and sensitivity, careful consideration must be given prior to their application to avoid possible confusion. Here, we provide an updated overview of a list of well-established immunological markers for the labeling of central glia, and discuss the cell-type specificity and stage dependency of their expression. Springer Nature Singapore 2022-08-26 /pmc/articles/PMC10043115/ /pubmed/36028641 http://dx.doi.org/10.1007/s12264-022-00938-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Huang, Hao He, Wanjun Tang, Tao Qiu, Mengsheng Immunological Markers for Central Nervous System Glia |
title | Immunological Markers for Central Nervous System Glia |
title_full | Immunological Markers for Central Nervous System Glia |
title_fullStr | Immunological Markers for Central Nervous System Glia |
title_full_unstemmed | Immunological Markers for Central Nervous System Glia |
title_short | Immunological Markers for Central Nervous System Glia |
title_sort | immunological markers for central nervous system glia |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043115/ https://www.ncbi.nlm.nih.gov/pubmed/36028641 http://dx.doi.org/10.1007/s12264-022-00938-2 |
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