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Coronary Artery Plaque Composition and Severity Relate to the Inflammasome in People With Treated Human Immunodeficiency Virus
BACKGROUND: Inflammasome activation is increased in people with human immunodeficiency virus (PWH), but its relationship with coronary plaque is poorly understood in this setting. METHODS: In a large human immunodeficiency virus cardiovascular prevention cohort, relationships between caspase-1, inte...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043127/ https://www.ncbi.nlm.nih.gov/pubmed/36998633 http://dx.doi.org/10.1093/ofid/ofad106 |
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| author | Schnittman, Samuel R Kitch, Douglas W Swartz, Talia H Burdo, Tricia H Fitch, Kathleen V McCallum, Sara Flynn, Jacqueline M Fulda, Evelynne S Diggs, Marissa R Stapleton, Jack T Casado, José L Taron, Jana Currier, Judith S Zanni, Markella V Malvestutto, Carlos Fichtenbaum, Carl J Aberg, Judith A Ribaudo, Heather J Lu, Michael T Douglas, Pamela S Grinspoon, Steven K |
| author_facet | Schnittman, Samuel R Kitch, Douglas W Swartz, Talia H Burdo, Tricia H Fitch, Kathleen V McCallum, Sara Flynn, Jacqueline M Fulda, Evelynne S Diggs, Marissa R Stapleton, Jack T Casado, José L Taron, Jana Currier, Judith S Zanni, Markella V Malvestutto, Carlos Fichtenbaum, Carl J Aberg, Judith A Ribaudo, Heather J Lu, Michael T Douglas, Pamela S Grinspoon, Steven K |
| author_sort | Schnittman, Samuel R |
| collection | PubMed |
| description | BACKGROUND: Inflammasome activation is increased in people with human immunodeficiency virus (PWH), but its relationship with coronary plaque is poorly understood in this setting. METHODS: In a large human immunodeficiency virus cardiovascular prevention cohort, relationships between caspase-1, interleukin (IL)-1β, and IL-18 and coronary plaque indices were assessed by multivariate logistic regression. RESULTS: Higher IL-18 and IL-1β were associated with Leaman score, an integrative measure of plaque burden and composition. CONCLUSIONS: As Leaman score >5 is associated with cardiovascular events in the general population, future work is needed to determine how the inflammasome relates to events and whether strategies to reduce its activation affect events or plaque progression among PWH. |
| format | Online Article Text |
| id | pubmed-10043127 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Oxford University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-100431272023-03-29 Coronary Artery Plaque Composition and Severity Relate to the Inflammasome in People With Treated Human Immunodeficiency Virus Schnittman, Samuel R Kitch, Douglas W Swartz, Talia H Burdo, Tricia H Fitch, Kathleen V McCallum, Sara Flynn, Jacqueline M Fulda, Evelynne S Diggs, Marissa R Stapleton, Jack T Casado, José L Taron, Jana Currier, Judith S Zanni, Markella V Malvestutto, Carlos Fichtenbaum, Carl J Aberg, Judith A Ribaudo, Heather J Lu, Michael T Douglas, Pamela S Grinspoon, Steven K Open Forum Infect Dis Brief Report BACKGROUND: Inflammasome activation is increased in people with human immunodeficiency virus (PWH), but its relationship with coronary plaque is poorly understood in this setting. METHODS: In a large human immunodeficiency virus cardiovascular prevention cohort, relationships between caspase-1, interleukin (IL)-1β, and IL-18 and coronary plaque indices were assessed by multivariate logistic regression. RESULTS: Higher IL-18 and IL-1β were associated with Leaman score, an integrative measure of plaque burden and composition. CONCLUSIONS: As Leaman score >5 is associated with cardiovascular events in the general population, future work is needed to determine how the inflammasome relates to events and whether strategies to reduce its activation affect events or plaque progression among PWH. Oxford University Press 2023-03-01 /pmc/articles/PMC10043127/ /pubmed/36998633 http://dx.doi.org/10.1093/ofid/ofad106 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
| spellingShingle | Brief Report Schnittman, Samuel R Kitch, Douglas W Swartz, Talia H Burdo, Tricia H Fitch, Kathleen V McCallum, Sara Flynn, Jacqueline M Fulda, Evelynne S Diggs, Marissa R Stapleton, Jack T Casado, José L Taron, Jana Currier, Judith S Zanni, Markella V Malvestutto, Carlos Fichtenbaum, Carl J Aberg, Judith A Ribaudo, Heather J Lu, Michael T Douglas, Pamela S Grinspoon, Steven K Coronary Artery Plaque Composition and Severity Relate to the Inflammasome in People With Treated Human Immunodeficiency Virus |
| title | Coronary Artery Plaque Composition and Severity Relate to the Inflammasome in People With Treated Human Immunodeficiency Virus |
| title_full | Coronary Artery Plaque Composition and Severity Relate to the Inflammasome in People With Treated Human Immunodeficiency Virus |
| title_fullStr | Coronary Artery Plaque Composition and Severity Relate to the Inflammasome in People With Treated Human Immunodeficiency Virus |
| title_full_unstemmed | Coronary Artery Plaque Composition and Severity Relate to the Inflammasome in People With Treated Human Immunodeficiency Virus |
| title_short | Coronary Artery Plaque Composition and Severity Relate to the Inflammasome in People With Treated Human Immunodeficiency Virus |
| title_sort | coronary artery plaque composition and severity relate to the inflammasome in people with treated human immunodeficiency virus |
| topic | Brief Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043127/ https://www.ncbi.nlm.nih.gov/pubmed/36998633 http://dx.doi.org/10.1093/ofid/ofad106 |
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