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The Oncogenesis of Glial Cells in Diffuse Gliomas and Clinical Opportunities

Glioma is the most common and lethal intrinsic primary tumor of the brain. Its controversial origins may contribute to its heterogeneity, creating challenges and difficulties in the development of therapies. Among the components constituting tumors, glioma stem cells are highly plastic subpopulation...

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Autores principales: Zhuang, Qiyuan, Yang, Hui, Mao, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043159/
https://www.ncbi.nlm.nih.gov/pubmed/36229714
http://dx.doi.org/10.1007/s12264-022-00953-3
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author Zhuang, Qiyuan
Yang, Hui
Mao, Ying
author_facet Zhuang, Qiyuan
Yang, Hui
Mao, Ying
author_sort Zhuang, Qiyuan
collection PubMed
description Glioma is the most common and lethal intrinsic primary tumor of the brain. Its controversial origins may contribute to its heterogeneity, creating challenges and difficulties in the development of therapies. Among the components constituting tumors, glioma stem cells are highly plastic subpopulations that are thought to be the site of tumor initiation. Neural stem cells/progenitor cells and oligodendrocyte progenitor cells are possible lineage groups populating the bulk of the tumor, in which gene mutations related to cell-cycle or metabolic enzymes dramatically affect this transformation. Novel approaches have revealed the tumor-promoting properties of distinct tumor cell states, glial, neural, and immune cell populations in the tumor microenvironment. Communication between tumor cells and other normal cells manipulate tumor progression and influence sensitivity to therapy. Here, we discuss the heterogeneity and relevant functions of tumor cell state, microglia, monocyte-derived macrophages, and neurons in glioma, highlighting their bilateral effects on tumors. Finally, we describe potential therapeutic approaches and targets beyond standard treatments.
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spelling pubmed-100431592023-03-29 The Oncogenesis of Glial Cells in Diffuse Gliomas and Clinical Opportunities Zhuang, Qiyuan Yang, Hui Mao, Ying Neurosci Bull Review Glioma is the most common and lethal intrinsic primary tumor of the brain. Its controversial origins may contribute to its heterogeneity, creating challenges and difficulties in the development of therapies. Among the components constituting tumors, glioma stem cells are highly plastic subpopulations that are thought to be the site of tumor initiation. Neural stem cells/progenitor cells and oligodendrocyte progenitor cells are possible lineage groups populating the bulk of the tumor, in which gene mutations related to cell-cycle or metabolic enzymes dramatically affect this transformation. Novel approaches have revealed the tumor-promoting properties of distinct tumor cell states, glial, neural, and immune cell populations in the tumor microenvironment. Communication between tumor cells and other normal cells manipulate tumor progression and influence sensitivity to therapy. Here, we discuss the heterogeneity and relevant functions of tumor cell state, microglia, monocyte-derived macrophages, and neurons in glioma, highlighting their bilateral effects on tumors. Finally, we describe potential therapeutic approaches and targets beyond standard treatments. Springer Nature Singapore 2022-10-13 /pmc/articles/PMC10043159/ /pubmed/36229714 http://dx.doi.org/10.1007/s12264-022-00953-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Zhuang, Qiyuan
Yang, Hui
Mao, Ying
The Oncogenesis of Glial Cells in Diffuse Gliomas and Clinical Opportunities
title The Oncogenesis of Glial Cells in Diffuse Gliomas and Clinical Opportunities
title_full The Oncogenesis of Glial Cells in Diffuse Gliomas and Clinical Opportunities
title_fullStr The Oncogenesis of Glial Cells in Diffuse Gliomas and Clinical Opportunities
title_full_unstemmed The Oncogenesis of Glial Cells in Diffuse Gliomas and Clinical Opportunities
title_short The Oncogenesis of Glial Cells in Diffuse Gliomas and Clinical Opportunities
title_sort oncogenesis of glial cells in diffuse gliomas and clinical opportunities
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043159/
https://www.ncbi.nlm.nih.gov/pubmed/36229714
http://dx.doi.org/10.1007/s12264-022-00953-3
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