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Sex differences in functional brain networks involved in interoception: An fMRI study
Interoception can be described as the ability to perceive inner body sensations and it is different between biological sex. However, no previous research correlated this ability with brain functional connectivity (FC) between males and females. In this study, we used resting-state functional magneti...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043182/ https://www.ncbi.nlm.nih.gov/pubmed/36998736 http://dx.doi.org/10.3389/fnins.2023.1130025 |
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author | Alfano, Vincenzo Cavaliere, Carlo Di Cecca, Angelica Ciccarelli, Giuseppina Salvatore, Marco Aiello, Marco Federico, Giovanni |
author_facet | Alfano, Vincenzo Cavaliere, Carlo Di Cecca, Angelica Ciccarelli, Giuseppina Salvatore, Marco Aiello, Marco Federico, Giovanni |
author_sort | Alfano, Vincenzo |
collection | PubMed |
description | Interoception can be described as the ability to perceive inner body sensations and it is different between biological sex. However, no previous research correlated this ability with brain functional connectivity (FC) between males and females. In this study, we used resting-state functional magnetic resonance imaging to investigate FC of networks involved in interoception among males and females in a sample of healthy volunteers matched for age. In total, 67 participants (34 females, mean age 44.2; 33 males, mean age 37.2) underwent a functional MRI session and completed the Self-Awareness Questionnaire (SAQ) that tests the interoceptive awareness. To assess the effect of sex on scores obtained on the SAQ we performed a multivariate analysis of variance. A whole-brain seed-to-seed FC analysis was conducted to investigate the correlation between SAQ score and FC, and then to test differences in FC between males and females with SAQ score as a covariate. MANOVA revealed a significant difference in SAQ scores between males and females with higher values for the second ones. Also, significant correlations among interoception scores and FC in Salience network and fronto-temporo-parietal brain areas have been detected, with a sharp prevalence for the female. These results support the idea of a female advantage in the attention toward interoceptive sensations, suggesting common inter-network areas that concur to create the sense of self. |
format | Online Article Text |
id | pubmed-10043182 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100431822023-03-29 Sex differences in functional brain networks involved in interoception: An fMRI study Alfano, Vincenzo Cavaliere, Carlo Di Cecca, Angelica Ciccarelli, Giuseppina Salvatore, Marco Aiello, Marco Federico, Giovanni Front Neurosci Neuroscience Interoception can be described as the ability to perceive inner body sensations and it is different between biological sex. However, no previous research correlated this ability with brain functional connectivity (FC) between males and females. In this study, we used resting-state functional magnetic resonance imaging to investigate FC of networks involved in interoception among males and females in a sample of healthy volunteers matched for age. In total, 67 participants (34 females, mean age 44.2; 33 males, mean age 37.2) underwent a functional MRI session and completed the Self-Awareness Questionnaire (SAQ) that tests the interoceptive awareness. To assess the effect of sex on scores obtained on the SAQ we performed a multivariate analysis of variance. A whole-brain seed-to-seed FC analysis was conducted to investigate the correlation between SAQ score and FC, and then to test differences in FC between males and females with SAQ score as a covariate. MANOVA revealed a significant difference in SAQ scores between males and females with higher values for the second ones. Also, significant correlations among interoception scores and FC in Salience network and fronto-temporo-parietal brain areas have been detected, with a sharp prevalence for the female. These results support the idea of a female advantage in the attention toward interoceptive sensations, suggesting common inter-network areas that concur to create the sense of self. Frontiers Media S.A. 2023-03-14 /pmc/articles/PMC10043182/ /pubmed/36998736 http://dx.doi.org/10.3389/fnins.2023.1130025 Text en Copyright © 2023 Alfano, Cavaliere, Di Cecca, Ciccarelli, Salvatore, Aiello and Federico. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Alfano, Vincenzo Cavaliere, Carlo Di Cecca, Angelica Ciccarelli, Giuseppina Salvatore, Marco Aiello, Marco Federico, Giovanni Sex differences in functional brain networks involved in interoception: An fMRI study |
title | Sex differences in functional brain networks involved in interoception: An fMRI study |
title_full | Sex differences in functional brain networks involved in interoception: An fMRI study |
title_fullStr | Sex differences in functional brain networks involved in interoception: An fMRI study |
title_full_unstemmed | Sex differences in functional brain networks involved in interoception: An fMRI study |
title_short | Sex differences in functional brain networks involved in interoception: An fMRI study |
title_sort | sex differences in functional brain networks involved in interoception: an fmri study |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043182/ https://www.ncbi.nlm.nih.gov/pubmed/36998736 http://dx.doi.org/10.3389/fnins.2023.1130025 |
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