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The multifaceted nature of endogenous cardiac regeneration

Since the first evidence of cardiac regeneration was observed, almost 50 years ago, more studies have highlighted the endogenous regenerative abilities of several models following cardiac injury. In particular, analysis of cardiac regeneration in zebrafish and neonatal mice has uncovered numerous me...

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Detalles Bibliográficos
Autores principales: Rolland, Laura, Jopling, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043193/
https://www.ncbi.nlm.nih.gov/pubmed/36998973
http://dx.doi.org/10.3389/fcvm.2023.1138485
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author Rolland, Laura
Jopling, Chris
author_facet Rolland, Laura
Jopling, Chris
author_sort Rolland, Laura
collection PubMed
description Since the first evidence of cardiac regeneration was observed, almost 50 years ago, more studies have highlighted the endogenous regenerative abilities of several models following cardiac injury. In particular, analysis of cardiac regeneration in zebrafish and neonatal mice has uncovered numerous mechanisms involved in the regenerative process. It is now apparent that cardiac regeneration is not simply achieved by inducing cardiomyocytes to proliferate but requires a multifaceted response involving numerous different cell types, signaling pathways and mechanisms which must all work in harmony in order for regeneration to occur. In this review we will endeavor to highlight a variety of processes that have been identifed as being essential for cardiac regeneration.
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spelling pubmed-100431932023-03-29 The multifaceted nature of endogenous cardiac regeneration Rolland, Laura Jopling, Chris Front Cardiovasc Med Cardiovascular Medicine Since the first evidence of cardiac regeneration was observed, almost 50 years ago, more studies have highlighted the endogenous regenerative abilities of several models following cardiac injury. In particular, analysis of cardiac regeneration in zebrafish and neonatal mice has uncovered numerous mechanisms involved in the regenerative process. It is now apparent that cardiac regeneration is not simply achieved by inducing cardiomyocytes to proliferate but requires a multifaceted response involving numerous different cell types, signaling pathways and mechanisms which must all work in harmony in order for regeneration to occur. In this review we will endeavor to highlight a variety of processes that have been identifed as being essential for cardiac regeneration. Frontiers Media S.A. 2023-03-14 /pmc/articles/PMC10043193/ /pubmed/36998973 http://dx.doi.org/10.3389/fcvm.2023.1138485 Text en Copyright © 2023 Rolland and Jopling. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Rolland, Laura
Jopling, Chris
The multifaceted nature of endogenous cardiac regeneration
title The multifaceted nature of endogenous cardiac regeneration
title_full The multifaceted nature of endogenous cardiac regeneration
title_fullStr The multifaceted nature of endogenous cardiac regeneration
title_full_unstemmed The multifaceted nature of endogenous cardiac regeneration
title_short The multifaceted nature of endogenous cardiac regeneration
title_sort multifaceted nature of endogenous cardiac regeneration
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043193/
https://www.ncbi.nlm.nih.gov/pubmed/36998973
http://dx.doi.org/10.3389/fcvm.2023.1138485
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