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Exposure to essential and non-essential trace elements and risks of congenital heart defects: A narrative review
Congenital heart defects (CHDs) are congenital abnormalities involving the gross structures of the heart and large blood vessels. Environmental factors, genetic factors and their interactions may contribute to the pathogenesis of CHDs. Generally, trace elements can be classified into essential trace...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043220/ https://www.ncbi.nlm.nih.gov/pubmed/36998909 http://dx.doi.org/10.3389/fnut.2023.1121826 |
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author | Liang, Yipu Pan, Zijian Zhu, Mingzheng Gao, Ruonan Wang, Yijue Cheng, Yijuan Zhang, Nannan |
author_facet | Liang, Yipu Pan, Zijian Zhu, Mingzheng Gao, Ruonan Wang, Yijue Cheng, Yijuan Zhang, Nannan |
author_sort | Liang, Yipu |
collection | PubMed |
description | Congenital heart defects (CHDs) are congenital abnormalities involving the gross structures of the heart and large blood vessels. Environmental factors, genetic factors and their interactions may contribute to the pathogenesis of CHDs. Generally, trace elements can be classified into essential trace elements and non-essential trace elements. Essential trace elements such as copper (Cu), zinc (Zn), iron (Fe), selenium (Se), and manganese (Mn) play important roles in human biological functions such as metabolic function, oxidative stress regulation, and embryonic development. Non-essential trace elements such as cadmium (Cd), arsenic (As), lead (Pb), nickle (Ni), barium (Ba), chromium (Cr) and mercury (Hg) are harmful to health even at low concentrations. Recent studies have revealed the potential involvement of these trace elements in the pathogenesis of CHDs. In this review, we summarized current studies exploring exposure to essential and non-essential trace elements and risks of CHDs, in order to provide further insights for the pathogenesis and prevention of CHDs. |
format | Online Article Text |
id | pubmed-10043220 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100432202023-03-29 Exposure to essential and non-essential trace elements and risks of congenital heart defects: A narrative review Liang, Yipu Pan, Zijian Zhu, Mingzheng Gao, Ruonan Wang, Yijue Cheng, Yijuan Zhang, Nannan Front Nutr Nutrition Congenital heart defects (CHDs) are congenital abnormalities involving the gross structures of the heart and large blood vessels. Environmental factors, genetic factors and their interactions may contribute to the pathogenesis of CHDs. Generally, trace elements can be classified into essential trace elements and non-essential trace elements. Essential trace elements such as copper (Cu), zinc (Zn), iron (Fe), selenium (Se), and manganese (Mn) play important roles in human biological functions such as metabolic function, oxidative stress regulation, and embryonic development. Non-essential trace elements such as cadmium (Cd), arsenic (As), lead (Pb), nickle (Ni), barium (Ba), chromium (Cr) and mercury (Hg) are harmful to health even at low concentrations. Recent studies have revealed the potential involvement of these trace elements in the pathogenesis of CHDs. In this review, we summarized current studies exploring exposure to essential and non-essential trace elements and risks of CHDs, in order to provide further insights for the pathogenesis and prevention of CHDs. Frontiers Media S.A. 2023-03-14 /pmc/articles/PMC10043220/ /pubmed/36998909 http://dx.doi.org/10.3389/fnut.2023.1121826 Text en Copyright © 2023 Liang, Pan, Zhu, Gao, Wang, Cheng and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Liang, Yipu Pan, Zijian Zhu, Mingzheng Gao, Ruonan Wang, Yijue Cheng, Yijuan Zhang, Nannan Exposure to essential and non-essential trace elements and risks of congenital heart defects: A narrative review |
title | Exposure to essential and non-essential trace elements and risks of congenital heart defects: A narrative review |
title_full | Exposure to essential and non-essential trace elements and risks of congenital heart defects: A narrative review |
title_fullStr | Exposure to essential and non-essential trace elements and risks of congenital heart defects: A narrative review |
title_full_unstemmed | Exposure to essential and non-essential trace elements and risks of congenital heart defects: A narrative review |
title_short | Exposure to essential and non-essential trace elements and risks of congenital heart defects: A narrative review |
title_sort | exposure to essential and non-essential trace elements and risks of congenital heart defects: a narrative review |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043220/ https://www.ncbi.nlm.nih.gov/pubmed/36998909 http://dx.doi.org/10.3389/fnut.2023.1121826 |
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