Cargando…

Ergothioneine, a dietary antioxidant improves amyloid beta clearance in the neuroretina of a mouse model of Alzheimer’s disease

INTRODUCTION: Ergothioneine (Ergo) is a naturally occurring dietary antioxidant. Ergo uptake is dependent on the transporter, organic cation transporter novel-type 1 (OCTN1) distribution. OCTN1 is highly expressed in blood cells (myeloid lineage cells), brain and ocular tissues that are likely predi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wijesinghe, Printha, Whitmore, Clayton A., Campbell, Matthew, Li, Charles, Tsuyuki, Miranda, To, Eleanor, Haynes, Justin, Pham, Wellington, Matsubara, Joanne A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043244/ https://www.ncbi.nlm.nih.gov/pubmed/36998724 http://dx.doi.org/10.3389/fnins.2023.1107436

Ejemplares similares

Longitudinal Consumption of Ergothioneine Reduces Oxidative Stress and Amyloid Plaques and Restores Glucose Metabolism in the 5XFAD Mouse Model of Alzheimer’s Disease
por: Whitmore, Clayton A., et al.
Publicado: (2022)

Inhalable Thioflavin S for the Detection of Amyloid Beta Deposits in the Retina
por: Barton, Shawn M., et al.
Publicado: (2021)

MicroRNAs in tear fluids predict underlying molecular changes associated with Alzheimer’s disease
por: Wijesinghe, Printha, et al.
Publicado: (2023)

A novel antioxidant ergothioneine PET radioligand for in vivo imaging applications
por: Behof, William J., et al.
Publicado: (2021)

Proapoptotic and survival signaling in the neuroretina at early stages of diabetic retinopathy
por: Valverde, Angela M., et al.
Publicado: (2013)

Ergothioneine: an underrecognised dietary micronutrient required for healthy ageing?
por: Tian, Xiaoying, et al.
Publicado: (2023)

Amyloid-beta and Alzheimer’s disease: the role of neprilysin-2 in amyloid-beta clearance
por: Marr, Robert A., et al.
Publicado: (2014)

Distribution and accumulation of dietary ergothioneine and its metabolites in mouse tissues
por: Tang, Richard Ming Yi, et al.
Publicado: (2018)

Ergothioneine, recent developments
por: Cheah, Irwin K., et al.
Publicado: (2021)

Toward more efficient ergothioneine production using the fungal ergothioneine biosynthetic pathway
por: Chen, Zhihui, et al.
Publicado: (2022)

Editorial on, “Amyloid-beta clearance in Alzheimer's disease”
por: Marr, Robert A.
Publicado: (2014)

Atrophy of the central neuroretina in patients treated for diabetic macular edema
por: Karst, Sonja G., et al.
Publicado: (2019)

Production of ergothioneine by Methylobacterium species
por: Alamgir, Kabir M., et al.
Publicado: (2015)

The biology of ergothioneine, an antioxidant nutraceutical
por: Borodina, Irina, et al.
Publicado: (2020)

Anticoagulants inhibit proteolytic clearance of plasma amyloid beta
por: Yang, Lu, et al.
Publicado: (2017)

Müller and macrophage-like cell interactions in an organotypic culture of porcine neuroretina
por: Fernandez-Bueno, Ivan, et al.
Publicado: (2008)

Multifunctional Interleukin-24 Resolves Neuroretina Autoimmunity via Diverse Mechanisms
por: Zhang, Xuan, et al.
Publicado: (2022)

Clearance of beta-amyloid is facilitated by apolipoprotein E and circulating high-density lipoproteins in bioengineered human vessels
por: Robert, Jerome, et al.
Publicado: (2017)

Increased tauopathy drives microglia-mediated clearance of beta-amyloid
por: Chen, Wesley, et al.
Publicado: (2016)

Clearance of amyloid‐beta with bispecific antibody constructs bound to erythrocytes
por: Taylor, Ronald P., et al.
Publicado: (2020)

Microglial amyloid beta clearance is driven by PIEZO1 channels
por: Jäntti, Henna, et al.
Publicado: (2022)

Role of Ergothioneine in Microbial Physiology and Pathogenesis
por: Cumming, Bridgette M., et al.
Publicado: (2018)

Engineering ergothioneine production in Yarrowia lipolytica
por: van der Hoek, Steven A., et al.
Publicado: (2021)

The role of amyloid beta clearance in cerebral amyloid angiopathy: more potential therapeutic targets
por: Qi, Xue-mei, et al.
Publicado: (2017)

Hypoxic Processes Induce Complement Activation via Classical Pathway in Porcine Neuroretinas
por: Mueller-Buehl, Ana M., et al.
Publicado: (2021)

Exploring the Origin and Physiological Significance of DNA Double Strand Breaks in the Developing Neuroretina
por: Álvarez-Lindo, Noemí, et al.
Publicado: (2022)

S-Methyl-L-Ergothioneine to L-Ergothioneine Ratio in Urine Is a Marker of Cystine Lithiasis in a Cystinuria Mouse Model
por: López de Heredia, Miguel, et al.
Publicado: (2021)

The Amyloid-Beta Clearance: From Molecular Targets to Glial and Neural Cells
por: Cai, Wenjun, et al.
Publicado: (2023)

Protein kinase C in porcine retinal arteries and neuroretina following retinal ischemia-reperfusion
por: Gesslein, Bodil, et al.
Publicado: (2009)

Specialized endothelial tip cells guide neuroretina vascularization and blood-retina-barrier formation
por: Zarkada, Georgia, et al.
Publicado: (2021)

Impaired lysosomes in the retinal pigment epithelium play a central role in the degeneration of the neuroretina
por: Miller, Rebecca D., et al.
Publicado: (2023)

MicroRNA Signature and Cellular Characterization of Undifferentiated and Differentiated House Ear Institute-Organ of Corti 1 (HEI-OC1) Cells
por: Wijesinghe, Printha, et al.
Publicado: (2022)

Could Ergothioneine Aid in the Treatment of Coronavirus Patients?
por: Cheah, Irwin K., et al.
Publicado: (2020)

Cryoprotective Effects of Ergothioneine and Isoespintanol on Canine Semen
por: Usuga, Alexandra, et al.
Publicado: (2021)

Protection against Doxorubicin-Induced Cardiotoxicity by Ergothioneine
por: Cheah, Irwin K., et al.
Publicado: (2023)

Protein Clearance Mechanisms of Alpha-Synuclein and Amyloid-Beta in Lewy Body Disorders
por: Deleidi, Michela, et al.
Publicado: (2012)

Physiological amyloid-beta clearance in the periphery and its therapeutic potential for Alzheimer’s disease
por: Xiang, Yang, et al.
Publicado: (2015)

Mitogen-activated protein kinases in the porcine retinal arteries and neuroretina following retinal ischemia-reperfusion
por: Gesslein, Bodil, et al.
Publicado: (2010)

A novel coculture model of porcine central neuroretina explants and retinal pigment epithelium cells
por: Di Lauro, Salvatore, et al.
Publicado: (2016)

Ergothioneine prevents endothelial dysfunction induced by mercury chloride
por: Gökçe, Göksel, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_rvcns6j81ltb7dcnn8p3oj13vb