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Risk of death following COVID-19 vaccination or positive SARS-CoV-2 test in young people in England

Several studies have reported associations between COVID-19 vaccination and risk of cardiac diseases, especially in young people; the impact on mortality, however, remains unclear. We use national, linked electronic health data in England to assess the impact of COVID-19 vaccination and positive SAR...

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Autores principales: Nafilyan, Vahé, Bermingham, Charlotte R., Ward, Isobel L., Morgan, Jasper, Zaccardi, Francesco, Khunti, Kamlesh, Stanborough, Julie, Banerjee, Amitava, Doidge, James C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043280/
https://www.ncbi.nlm.nih.gov/pubmed/36973247
http://dx.doi.org/10.1038/s41467-023-36494-0
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author Nafilyan, Vahé
Bermingham, Charlotte R.
Ward, Isobel L.
Morgan, Jasper
Zaccardi, Francesco
Khunti, Kamlesh
Stanborough, Julie
Banerjee, Amitava
Doidge, James C.
author_facet Nafilyan, Vahé
Bermingham, Charlotte R.
Ward, Isobel L.
Morgan, Jasper
Zaccardi, Francesco
Khunti, Kamlesh
Stanborough, Julie
Banerjee, Amitava
Doidge, James C.
author_sort Nafilyan, Vahé
collection PubMed
description Several studies have reported associations between COVID-19 vaccination and risk of cardiac diseases, especially in young people; the impact on mortality, however, remains unclear. We use national, linked electronic health data in England to assess the impact of COVID-19 vaccination and positive SARS-CoV-2 tests on the risk of cardiac and all-cause mortality in young people (12 to 29 years) using a self-controlled case series design. Here, we show there is no significant increase in cardiac or all-cause mortality in the 12 weeks following COVID-19 vaccination compared to more than 12 weeks after any dose. However, we find an increase in cardiac death in women after a first dose of non mRNA vaccines. A positive SARS-CoV-2 test is associated with increased cardiac and all-cause mortality among people vaccinated or unvaccinated at time of testing.
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spelling pubmed-100432802023-03-29 Risk of death following COVID-19 vaccination or positive SARS-CoV-2 test in young people in England Nafilyan, Vahé Bermingham, Charlotte R. Ward, Isobel L. Morgan, Jasper Zaccardi, Francesco Khunti, Kamlesh Stanborough, Julie Banerjee, Amitava Doidge, James C. Nat Commun Article Several studies have reported associations between COVID-19 vaccination and risk of cardiac diseases, especially in young people; the impact on mortality, however, remains unclear. We use national, linked electronic health data in England to assess the impact of COVID-19 vaccination and positive SARS-CoV-2 tests on the risk of cardiac and all-cause mortality in young people (12 to 29 years) using a self-controlled case series design. Here, we show there is no significant increase in cardiac or all-cause mortality in the 12 weeks following COVID-19 vaccination compared to more than 12 weeks after any dose. However, we find an increase in cardiac death in women after a first dose of non mRNA vaccines. A positive SARS-CoV-2 test is associated with increased cardiac and all-cause mortality among people vaccinated or unvaccinated at time of testing. Nature Publishing Group UK 2023-03-27 /pmc/articles/PMC10043280/ /pubmed/36973247 http://dx.doi.org/10.1038/s41467-023-36494-0 Text en © Crown 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Nafilyan, Vahé
Bermingham, Charlotte R.
Ward, Isobel L.
Morgan, Jasper
Zaccardi, Francesco
Khunti, Kamlesh
Stanborough, Julie
Banerjee, Amitava
Doidge, James C.
Risk of death following COVID-19 vaccination or positive SARS-CoV-2 test in young people in England
title Risk of death following COVID-19 vaccination or positive SARS-CoV-2 test in young people in England
title_full Risk of death following COVID-19 vaccination or positive SARS-CoV-2 test in young people in England
title_fullStr Risk of death following COVID-19 vaccination or positive SARS-CoV-2 test in young people in England
title_full_unstemmed Risk of death following COVID-19 vaccination or positive SARS-CoV-2 test in young people in England
title_short Risk of death following COVID-19 vaccination or positive SARS-CoV-2 test in young people in England
title_sort risk of death following covid-19 vaccination or positive sars-cov-2 test in young people in england
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043280/
https://www.ncbi.nlm.nih.gov/pubmed/36973247
http://dx.doi.org/10.1038/s41467-023-36494-0
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