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FBXW7 attenuates tumor drug resistance and enhances the efficacy of immunotherapy

FBXW7 (F-box and WD repeat domain containing 7) is a critical subunit of the Skp1-Cullin1-F-box protein (SCF), acting as an E3 ubiquitin ligase by ubiquitinating targeted protein. Through degradation of its substrates, FBXW7 plays a pivotal role in drug resistance in tumor cells and shows the potent...

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Detalles Bibliográficos
Autores principales:	Chen, Shimin, Lin, Jichun, Zhao, Jiaojiao, Lin, Qian, Liu, Jia, Wang, Qiang, Mui, Ryan, Ma, Leina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043335/ https://www.ncbi.nlm.nih.gov/pubmed/36998461 http://dx.doi.org/10.3389/fonc.2023.1147239

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