The advancements in targets for ferroptosis in liver diseases

Ferroptosis is a type of regulated cell death caused by iron overload and lipid peroxidation, and its core is an imbalance of redox reactions. Recent studies showed that ferroptosis played a dual role in liver diseases, that was, as a therapeutic target and a pathogenic factor. Therefore, herein, we...

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Autores principales: Xiang, Xiaohong, Gao, Jianbo, Su, Danyang, Shi, Doudou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043409/
https://www.ncbi.nlm.nih.gov/pubmed/36999078
http://dx.doi.org/10.3389/fmed.2023.1084479
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author Xiang, Xiaohong
Gao, Jianbo
Su, Danyang
Shi, Doudou
author_facet Xiang, Xiaohong
Gao, Jianbo
Su, Danyang
Shi, Doudou
author_sort Xiang, Xiaohong
collection PubMed
description Ferroptosis is a type of regulated cell death caused by iron overload and lipid peroxidation, and its core is an imbalance of redox reactions. Recent studies showed that ferroptosis played a dual role in liver diseases, that was, as a therapeutic target and a pathogenic factor. Therefore, herein, we summarized the role of ferroptosis in liver diseases, reviewed the part of available targets, such as drugs, small molecules, and nanomaterials, that acted on ferroptosis in liver diseases, and discussed the current challenges and prospects.
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spelling pubmed-100434092023-03-29 The advancements in targets for ferroptosis in liver diseases Xiang, Xiaohong Gao, Jianbo Su, Danyang Shi, Doudou Front Med (Lausanne) Medicine Ferroptosis is a type of regulated cell death caused by iron overload and lipid peroxidation, and its core is an imbalance of redox reactions. Recent studies showed that ferroptosis played a dual role in liver diseases, that was, as a therapeutic target and a pathogenic factor. Therefore, herein, we summarized the role of ferroptosis in liver diseases, reviewed the part of available targets, such as drugs, small molecules, and nanomaterials, that acted on ferroptosis in liver diseases, and discussed the current challenges and prospects. Frontiers Media S.A. 2023-03-14 /pmc/articles/PMC10043409/ /pubmed/36999078 http://dx.doi.org/10.3389/fmed.2023.1084479 Text en Copyright © 2023 Xiang, Gao, Su and Shi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Xiang, Xiaohong
Gao, Jianbo
Su, Danyang
Shi, Doudou
The advancements in targets for ferroptosis in liver diseases
title The advancements in targets for ferroptosis in liver diseases
title_full The advancements in targets for ferroptosis in liver diseases
title_fullStr The advancements in targets for ferroptosis in liver diseases
title_full_unstemmed The advancements in targets for ferroptosis in liver diseases
title_short The advancements in targets for ferroptosis in liver diseases
title_sort advancements in targets for ferroptosis in liver diseases
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043409/
https://www.ncbi.nlm.nih.gov/pubmed/36999078
http://dx.doi.org/10.3389/fmed.2023.1084479
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