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Recent advances in the crosstalk between adipose, muscle and bone tissues in fish

Control of tissue metabolism and growth involves interactions between organs, tissues, and cell types, mediated by cytokines or direct communication through cellular exchanges. Indeed, over the past decades, many peptides produced by adipose tissue, skeletal muscle and bone named adipokines, myokine...

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Autores principales: Hue, Isabelle, Capilla, Encarnación, Rosell-Moll, Enrique, Balbuena-Pecino, Sara, Goffette, Valentine, Gabillard, Jean-Charles, Navarro, Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043431/
https://www.ncbi.nlm.nih.gov/pubmed/36998471
http://dx.doi.org/10.3389/fendo.2023.1155202
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author Hue, Isabelle
Capilla, Encarnación
Rosell-Moll, Enrique
Balbuena-Pecino, Sara
Goffette, Valentine
Gabillard, Jean-Charles
Navarro, Isabel
author_facet Hue, Isabelle
Capilla, Encarnación
Rosell-Moll, Enrique
Balbuena-Pecino, Sara
Goffette, Valentine
Gabillard, Jean-Charles
Navarro, Isabel
author_sort Hue, Isabelle
collection PubMed
description Control of tissue metabolism and growth involves interactions between organs, tissues, and cell types, mediated by cytokines or direct communication through cellular exchanges. Indeed, over the past decades, many peptides produced by adipose tissue, skeletal muscle and bone named adipokines, myokines and osteokines respectively, have been identified in mammals playing key roles in organ/tissue development and function. Some of them are released into the circulation acting as classical hormones, but they can also act locally showing autocrine/paracrine effects. In recent years, some of these cytokines have been identified in fish models of biomedical or agronomic interest. In this review, we will present their state of the art focusing on local actions and inter-tissue effects. Adipokines reported in fish adipocytes include adiponectin and leptin among others. We will focus on their structure characteristics, gene expression, receptors, and effects, in the adipose tissue itself, mainly regulating cell differentiation and metabolism, but in muscle and bone as target tissues too. Moreover, lipid metabolites, named lipokines, can also act as signaling molecules regulating metabolic homeostasis. Regarding myokines, the best documented in fish are myostatin and the insulin-like growth factors. This review summarizes their characteristics at a molecular level, and describes both, autocrine effects and interactions with adipose tissue and bone. Nonetheless, our understanding of the functions and mechanisms of action of many of these cytokines is still largely incomplete in fish, especially concerning osteokines (i.e., osteocalcin), whose potential cross talking roles remain to be elucidated. Furthermore, by using selective breeding or genetic tools, the formation of a specific tissue can be altered, highlighting the consequences on other tissues, and allowing the identification of communication signals. The specific effects of identified cytokines validated through in vitro models or in vivo trials will be described. Moreover, future scientific fronts (i.e., exosomes) and tools (i.e., co-cultures, organoids) for a better understanding of inter-organ crosstalk in fish will also be presented. As a final consideration, further identification of molecules involved in inter-tissue communication will open new avenues of knowledge in the control of fish homeostasis, as well as possible strategies to be applied in aquaculture or biomedicine.
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spelling pubmed-100434312023-03-29 Recent advances in the crosstalk between adipose, muscle and bone tissues in fish Hue, Isabelle Capilla, Encarnación Rosell-Moll, Enrique Balbuena-Pecino, Sara Goffette, Valentine Gabillard, Jean-Charles Navarro, Isabel Front Endocrinol (Lausanne) Endocrinology Control of tissue metabolism and growth involves interactions between organs, tissues, and cell types, mediated by cytokines or direct communication through cellular exchanges. Indeed, over the past decades, many peptides produced by adipose tissue, skeletal muscle and bone named adipokines, myokines and osteokines respectively, have been identified in mammals playing key roles in organ/tissue development and function. Some of them are released into the circulation acting as classical hormones, but they can also act locally showing autocrine/paracrine effects. In recent years, some of these cytokines have been identified in fish models of biomedical or agronomic interest. In this review, we will present their state of the art focusing on local actions and inter-tissue effects. Adipokines reported in fish adipocytes include adiponectin and leptin among others. We will focus on their structure characteristics, gene expression, receptors, and effects, in the adipose tissue itself, mainly regulating cell differentiation and metabolism, but in muscle and bone as target tissues too. Moreover, lipid metabolites, named lipokines, can also act as signaling molecules regulating metabolic homeostasis. Regarding myokines, the best documented in fish are myostatin and the insulin-like growth factors. This review summarizes their characteristics at a molecular level, and describes both, autocrine effects and interactions with adipose tissue and bone. Nonetheless, our understanding of the functions and mechanisms of action of many of these cytokines is still largely incomplete in fish, especially concerning osteokines (i.e., osteocalcin), whose potential cross talking roles remain to be elucidated. Furthermore, by using selective breeding or genetic tools, the formation of a specific tissue can be altered, highlighting the consequences on other tissues, and allowing the identification of communication signals. The specific effects of identified cytokines validated through in vitro models or in vivo trials will be described. Moreover, future scientific fronts (i.e., exosomes) and tools (i.e., co-cultures, organoids) for a better understanding of inter-organ crosstalk in fish will also be presented. As a final consideration, further identification of molecules involved in inter-tissue communication will open new avenues of knowledge in the control of fish homeostasis, as well as possible strategies to be applied in aquaculture or biomedicine. Frontiers Media S.A. 2023-03-14 /pmc/articles/PMC10043431/ /pubmed/36998471 http://dx.doi.org/10.3389/fendo.2023.1155202 Text en Copyright © 2023 Hue, Capilla, Rosell-Moll, Balbuena-Pecino, Goffette, Gabillard and Navarro https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Hue, Isabelle
Capilla, Encarnación
Rosell-Moll, Enrique
Balbuena-Pecino, Sara
Goffette, Valentine
Gabillard, Jean-Charles
Navarro, Isabel
Recent advances in the crosstalk between adipose, muscle and bone tissues in fish
title Recent advances in the crosstalk between adipose, muscle and bone tissues in fish
title_full Recent advances in the crosstalk between adipose, muscle and bone tissues in fish
title_fullStr Recent advances in the crosstalk between adipose, muscle and bone tissues in fish
title_full_unstemmed Recent advances in the crosstalk between adipose, muscle and bone tissues in fish
title_short Recent advances in the crosstalk between adipose, muscle and bone tissues in fish
title_sort recent advances in the crosstalk between adipose, muscle and bone tissues in fish
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043431/
https://www.ncbi.nlm.nih.gov/pubmed/36998471
http://dx.doi.org/10.3389/fendo.2023.1155202
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