A Novel Deep-Learning-Based CADx Architecture for Classification of Thyroid Nodules Using Ultrasound Images

Nodules of thyroid cancer occur in the cells of the thyroid as benign or malign types. Thyroid sonographic images are mostly used for diagnosis of thyroid cancer. The aim of this study is to introduce a computer-aided diagnosis system that can classify the thyroid nodules with high accuracy using the data gathered from ultrasound images. Acquisition and labeling of sub-images were performed by a specialist physician. Then the number of these sub-images were increased using data augmentation methods. Deep features were obtained from the images using a pre-trained deep neural network. The dimensions of the features were reduced and features were improved. The improved features were combined with morphological and texture features. This feature group was rated by a value called similarity coefficient value which was obtained from a similarity coefficient generator module. The nodules were classified as benign or malignant using a multi-layer deep neural network with a pre-weighting layer designed with a novel approach. In this study, a novel multi-layer computer-aided diagnosis system was proposed for thyroid cancer detection. In the first layer of the system, a novel feature extraction method based on the class similarity of images was developed. In the second layer, a novel pre-weighting layer was proposed by modifying the genetic algorithm. The proposed system showed superior performance in different metrics compared to the literature. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12539-023-00560-4.