Isolation and Characterization of Anti-Mycobacterial Natural Products from a Petrosia sp. Marine Sponge

[Image: see text] Tuberculosis (TB) is a dreadful infectious disease and a leading cause of mortality and morbidity worldwide, second in 2020 only to severe acute respiratory syndrome 2 (SARS-Cov-2). With limited therapeutic options available and a rise in multidrug-resistant tuberculosis cases, it...

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Autores principales: Khatri Chhetri, Bhuwan, Bhanushali, Riya, Liang, Yifan, Cepeda, Marisa R., Niradininoco, Adi Kula, Soapi, Katy, Wan, Baojie, Qader, Mallique, Franzblau, Scott G., Kubanek, Julia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society and American Society of Pharmacognosy 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043868/
https://www.ncbi.nlm.nih.gov/pubmed/36881908
http://dx.doi.org/10.1021/acs.jnatprod.2c01003
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author Khatri Chhetri, Bhuwan
Bhanushali, Riya
Liang, Yifan
Cepeda, Marisa R.
Niradininoco, Adi Kula
Soapi, Katy
Wan, Baojie
Qader, Mallique
Franzblau, Scott G.
Kubanek, Julia
author_facet Khatri Chhetri, Bhuwan
Bhanushali, Riya
Liang, Yifan
Cepeda, Marisa R.
Niradininoco, Adi Kula
Soapi, Katy
Wan, Baojie
Qader, Mallique
Franzblau, Scott G.
Kubanek, Julia
author_sort Khatri Chhetri, Bhuwan
collection PubMed
description [Image: see text] Tuberculosis (TB) is a dreadful infectious disease and a leading cause of mortality and morbidity worldwide, second in 2020 only to severe acute respiratory syndrome 2 (SARS-Cov-2). With limited therapeutic options available and a rise in multidrug-resistant tuberculosis cases, it is critical to develop antibiotic drugs that display novel mechanisms of action. Bioactivity-guided fractionation employing an Alamar blue assay for Mycobacterium tuberculosis strain H37Rv led to the isolation of duryne (13) from a marine sponge Petrosia sp. sampled in the Solomon Islands. Additionally, five new strongylophorine meroditerpene analogues (1–5) along with six known strongylophorines (6–12) were isolated from the bioactive fraction and characterized using MS and NMR spectroscopy, although only 13 exhibited antitubercular activity.
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spelling pubmed-100438682023-03-29 Isolation and Characterization of Anti-Mycobacterial Natural Products from a Petrosia sp. Marine Sponge Khatri Chhetri, Bhuwan Bhanushali, Riya Liang, Yifan Cepeda, Marisa R. Niradininoco, Adi Kula Soapi, Katy Wan, Baojie Qader, Mallique Franzblau, Scott G. Kubanek, Julia J Nat Prod [Image: see text] Tuberculosis (TB) is a dreadful infectious disease and a leading cause of mortality and morbidity worldwide, second in 2020 only to severe acute respiratory syndrome 2 (SARS-Cov-2). With limited therapeutic options available and a rise in multidrug-resistant tuberculosis cases, it is critical to develop antibiotic drugs that display novel mechanisms of action. Bioactivity-guided fractionation employing an Alamar blue assay for Mycobacterium tuberculosis strain H37Rv led to the isolation of duryne (13) from a marine sponge Petrosia sp. sampled in the Solomon Islands. Additionally, five new strongylophorine meroditerpene analogues (1–5) along with six known strongylophorines (6–12) were isolated from the bioactive fraction and characterized using MS and NMR spectroscopy, although only 13 exhibited antitubercular activity. American Chemical Society and American Society of Pharmacognosy 2023-03-07 /pmc/articles/PMC10043868/ /pubmed/36881908 http://dx.doi.org/10.1021/acs.jnatprod.2c01003 Text en © 2023 The Authors. Published by American Chemical Society and American Society of Pharmacognosy https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Khatri Chhetri, Bhuwan
Bhanushali, Riya
Liang, Yifan
Cepeda, Marisa R.
Niradininoco, Adi Kula
Soapi, Katy
Wan, Baojie
Qader, Mallique
Franzblau, Scott G.
Kubanek, Julia
Isolation and Characterization of Anti-Mycobacterial Natural Products from a Petrosia sp. Marine Sponge
title Isolation and Characterization of Anti-Mycobacterial Natural Products from a Petrosia sp. Marine Sponge
title_full Isolation and Characterization of Anti-Mycobacterial Natural Products from a Petrosia sp. Marine Sponge
title_fullStr Isolation and Characterization of Anti-Mycobacterial Natural Products from a Petrosia sp. Marine Sponge
title_full_unstemmed Isolation and Characterization of Anti-Mycobacterial Natural Products from a Petrosia sp. Marine Sponge
title_short Isolation and Characterization of Anti-Mycobacterial Natural Products from a Petrosia sp. Marine Sponge
title_sort isolation and characterization of anti-mycobacterial natural products from a petrosia sp. marine sponge
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043868/
https://www.ncbi.nlm.nih.gov/pubmed/36881908
http://dx.doi.org/10.1021/acs.jnatprod.2c01003
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