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Stable and Reusable Lace-like Black Silicon Nanostructures Coated with Nanometer-Thick Gold Films for SERS-Based Sensing

[Image: see text] We propose a simple, fast, and low-cost method for producing Au-coated black Si-based SERS-active substrates with a proven enhancement factor of 10(6). Room temperature reactive ion etching of silicon wafer followed by nanometer-thin gold sputtering allows the formation of a highly...

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Autores principales: Golubewa, Lena, Klimovich, Aliona, Timoshchenko, Igor, Padrez, Yaraslau, Fetisova, Marina, Rehman, Hamza, Karvinen, Petri, Selskis, Algirdas, Adomavičiu̅tė-Grabusovė, Sonata, Matulaitienė, Ieva, Ramanavicius, Arunas, Karpicz, Renata, Kulahava, Tatsiana, Svirko, Yuri, Kuzhir, Polina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043874/
https://www.ncbi.nlm.nih.gov/pubmed/37006910
http://dx.doi.org/10.1021/acsanm.3c00281
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author Golubewa, Lena
Klimovich, Aliona
Timoshchenko, Igor
Padrez, Yaraslau
Fetisova, Marina
Rehman, Hamza
Karvinen, Petri
Selskis, Algirdas
Adomavičiu̅tė-Grabusovė, Sonata
Matulaitienė, Ieva
Ramanavicius, Arunas
Karpicz, Renata
Kulahava, Tatsiana
Svirko, Yuri
Kuzhir, Polina
author_facet Golubewa, Lena
Klimovich, Aliona
Timoshchenko, Igor
Padrez, Yaraslau
Fetisova, Marina
Rehman, Hamza
Karvinen, Petri
Selskis, Algirdas
Adomavičiu̅tė-Grabusovė, Sonata
Matulaitienė, Ieva
Ramanavicius, Arunas
Karpicz, Renata
Kulahava, Tatsiana
Svirko, Yuri
Kuzhir, Polina
author_sort Golubewa, Lena
collection PubMed
description [Image: see text] We propose a simple, fast, and low-cost method for producing Au-coated black Si-based SERS-active substrates with a proven enhancement factor of 10(6). Room temperature reactive ion etching of silicon wafer followed by nanometer-thin gold sputtering allows the formation of a highly developed lace-type Si surface covered with homogeneously distributed gold islands. The mosaic structure of deposited gold allows the use of Au-uncovered Si domains for Raman peak intensity normalization. The fabricated SERS substrates have prominent uniformity (with less than 6% SERS signal variations over large areas, 100 × 100 μm(2)). It has been found that the storage of SERS-active substrates in an ambient environment reduces the SERS signal by less than 3% in 1 month and not more than 40% in 20 months. We showed that Au-coated black Si-based SERS-active substrates can be reused after oxygen plasma cleaning and developed relevant protocols for removing covalently bonded and electrostatically attached molecules. Experiments revealed that the Raman signal of 4-MBA molecules covalently bonded to the Au coating measured after the 10th cycle was just 4 times lower than that observed for the virgin substrate. A case study of the reusability of the black Si-based substrate was conducted for the subsequent detection of 10(–5) M doxorubicin, a widely used anticancer drug, after the reuse cycle. The obtained SERS spectra of doxorubicin were highly reproducible. We demonstrated that the fabricated substrate permits not only qualitative but also quantitative monitoring of analytes and is suitable for the determination of concentrations of doxorubicin in the range of 10(–9)–10(–4) M. Reusable, stable, reliable, durable, low-cost Au-coated black Si-based SERS-active substrates are promising tools for routine laboratory research in different areas of science and healthcare.
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spelling pubmed-100438742023-03-29 Stable and Reusable Lace-like Black Silicon Nanostructures Coated with Nanometer-Thick Gold Films for SERS-Based Sensing Golubewa, Lena Klimovich, Aliona Timoshchenko, Igor Padrez, Yaraslau Fetisova, Marina Rehman, Hamza Karvinen, Petri Selskis, Algirdas Adomavičiu̅tė-Grabusovė, Sonata Matulaitienė, Ieva Ramanavicius, Arunas Karpicz, Renata Kulahava, Tatsiana Svirko, Yuri Kuzhir, Polina ACS Appl Nano Mater [Image: see text] We propose a simple, fast, and low-cost method for producing Au-coated black Si-based SERS-active substrates with a proven enhancement factor of 10(6). Room temperature reactive ion etching of silicon wafer followed by nanometer-thin gold sputtering allows the formation of a highly developed lace-type Si surface covered with homogeneously distributed gold islands. The mosaic structure of deposited gold allows the use of Au-uncovered Si domains for Raman peak intensity normalization. The fabricated SERS substrates have prominent uniformity (with less than 6% SERS signal variations over large areas, 100 × 100 μm(2)). It has been found that the storage of SERS-active substrates in an ambient environment reduces the SERS signal by less than 3% in 1 month and not more than 40% in 20 months. We showed that Au-coated black Si-based SERS-active substrates can be reused after oxygen plasma cleaning and developed relevant protocols for removing covalently bonded and electrostatically attached molecules. Experiments revealed that the Raman signal of 4-MBA molecules covalently bonded to the Au coating measured after the 10th cycle was just 4 times lower than that observed for the virgin substrate. A case study of the reusability of the black Si-based substrate was conducted for the subsequent detection of 10(–5) M doxorubicin, a widely used anticancer drug, after the reuse cycle. The obtained SERS spectra of doxorubicin were highly reproducible. We demonstrated that the fabricated substrate permits not only qualitative but also quantitative monitoring of analytes and is suitable for the determination of concentrations of doxorubicin in the range of 10(–9)–10(–4) M. Reusable, stable, reliable, durable, low-cost Au-coated black Si-based SERS-active substrates are promising tools for routine laboratory research in different areas of science and healthcare. American Chemical Society 2023-03-09 /pmc/articles/PMC10043874/ /pubmed/37006910 http://dx.doi.org/10.1021/acsanm.3c00281 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Golubewa, Lena
Klimovich, Aliona
Timoshchenko, Igor
Padrez, Yaraslau
Fetisova, Marina
Rehman, Hamza
Karvinen, Petri
Selskis, Algirdas
Adomavičiu̅tė-Grabusovė, Sonata
Matulaitienė, Ieva
Ramanavicius, Arunas
Karpicz, Renata
Kulahava, Tatsiana
Svirko, Yuri
Kuzhir, Polina
Stable and Reusable Lace-like Black Silicon Nanostructures Coated with Nanometer-Thick Gold Films for SERS-Based Sensing
title Stable and Reusable Lace-like Black Silicon Nanostructures Coated with Nanometer-Thick Gold Films for SERS-Based Sensing
title_full Stable and Reusable Lace-like Black Silicon Nanostructures Coated with Nanometer-Thick Gold Films for SERS-Based Sensing
title_fullStr Stable and Reusable Lace-like Black Silicon Nanostructures Coated with Nanometer-Thick Gold Films for SERS-Based Sensing
title_full_unstemmed Stable and Reusable Lace-like Black Silicon Nanostructures Coated with Nanometer-Thick Gold Films for SERS-Based Sensing
title_short Stable and Reusable Lace-like Black Silicon Nanostructures Coated with Nanometer-Thick Gold Films for SERS-Based Sensing
title_sort stable and reusable lace-like black silicon nanostructures coated with nanometer-thick gold films for sers-based sensing
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043874/
https://www.ncbi.nlm.nih.gov/pubmed/37006910
http://dx.doi.org/10.1021/acsanm.3c00281
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