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Rapid deracemization through solvent cycling: proof-of-concept using a racemizable conglomerate clopidogrel precursor
We demonstrate that a conglomerate-forming clopidogrel precursor undergoing solution phase racemization can be deracemized through cyclic solvent removal and re-addition. We establish that the combination of slow growth and fast dissolution of crystals is ideal for rapid deracemization, which we ach...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043878/ https://www.ncbi.nlm.nih.gov/pubmed/36825774 http://dx.doi.org/10.1039/d3cc00332a |