Biotransformation of Efavirenz and Proteomic Analysis of Cytochrome P450s and UDP-Glucuronosyltransferases in Mouse, Macaque, and Human Brain-Derived In Vitro Systems

Antiretroviral drugs such as efavirenz (EFV) are essential to combat human immunodeficiency virus (HIV) infection in the brain, but little is known about how these drugs are metabolized locally. In this study, the cytochrome P450 (P450) and UDP-glucuronosyltransferase (UGT)-dependent metabolism of E...

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Detalles Bibliográficos
Autores principales: Wheeler, Abigail M., Orsburn, Benjamin C., Bumpus, Namandjé N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043944/
https://www.ncbi.nlm.nih.gov/pubmed/36623884
http://dx.doi.org/10.1124/dmd.122.001195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043944/
https://www.ncbi.nlm.nih.gov/pubmed/36623884
http://dx.doi.org/10.1124/dmd.122.001195

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