Synthesis of deuterated S-217622 (Ensitrelvir) with antiviral activity against coronaviruses including SARS-CoV-2

S-217622 (Ensitrelvir) is a reversible severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) 3-chymotrypsin-like protease (3CL(pro)) inhibitor which obtained emergency regulatory approval in Japan for the treatment of SARS-CoV-2 infection on Nov 22, 2022. Herein, analogs of S-271622 with deut...

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Detalles Bibliográficos
Autores principales: Yang, Yujian, Cao, Liu, Yan, Ming, Zhou, Jun, Yang, Sidi, Xu, Tiefeng, Huang, Siyao, Li, Kun, Zhou, Qifan, Li, Guanguan, Zhu, Yujun, Cong, Feng, Zhang, Hongmin, Guo, Deyin, Li, Yingjun, Zhang, Xumu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier B.V. 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10043954/
https://www.ncbi.nlm.nih.gov/pubmed/36997073
http://dx.doi.org/10.1016/j.antiviral.2023.105586

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