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Structural and functional characterization of the cytotoxic protein ledodin, an atypical ribosome‐inactivating protein from shiitake mushroom (Lentinula edodes)

We have purified ledodin, a cytotoxic 22‐kDa protein from shiitake mushroom (Lentinula edodes) consisting of a 197 amino acid chain. Ledodin possessed N‐glycosylase activity on the sarcin‐ricin loop of mammalian 28S rRNA and inhibited protein synthesis. However, it was not active against insect, fun...

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Detalles Bibliográficos
Autores principales:	Citores, Lucía, Ragucci, Sara, Russo, Rosita, Gay, Claudia C., Chambery, Angela, Di Maro, Antimo, Iglesias, Rosario, Ferreras, José M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2023
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10044108/ https://www.ncbi.nlm.nih.gov/pubmed/36905289 http://dx.doi.org/10.1002/pro.4621

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