Cargando…

Iloprost for the treatment of frostbite: a scoping review

We performed a scoping review to identify the extent of the literature describing the use of iloprost in the treatment of frostbite. Iloprost is a stable synthetic analog of prostaglandin I(2). As a potent inhibitor of platelet aggregation and vasodilator, it has been used to address the post-rewarm...

Descripción completa

Detalles Bibliográficos
Autores principales: Gauthier, Josianne, Morris-Janzen, Dunavan, Poole, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10044161/
https://www.ncbi.nlm.nih.gov/pubmed/36966492
http://dx.doi.org/10.1080/22423982.2023.2189552
_version_ 1784913306577797120
author Gauthier, Josianne
Morris-Janzen, Dunavan
Poole, Alexander
author_facet Gauthier, Josianne
Morris-Janzen, Dunavan
Poole, Alexander
author_sort Gauthier, Josianne
collection PubMed
description We performed a scoping review to identify the extent of the literature describing the use of iloprost in the treatment of frostbite. Iloprost is a stable synthetic analog of prostaglandin I(2). As a potent inhibitor of platelet aggregation and vasodilator, it has been used to address the post-rewarming reperfusion injury in frostbite. The search using iloprost and frostbite as key words and MeSH terms yielded 200 articles. We included in our review the literature examining iloprost for the treatment of frostbite in humans in the form of primary research, conference proceedings and abstracts. Twenty studies published from 1994 to 2022 were selected for analysis. The majority were retrospective case series consisting of a homogeneous population of mountain sport enthusiasts. A total of 254 patients and over 1000 frostbitten digits were included among the 20 studies. The larger case series demonstrated a decrease in amputation rates relative to untreated patients. Primary gaps in the literature include a paucity of randomised trials and relatively limited study populations to date. While the case evidence is promising, a multi-centre collaboration would be crucial to adequately power prospective randomised studies to definitively determine if iloprost has a role in the treatment of frostbite.
format Online
Article
Text
id pubmed-10044161
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-100441612023-03-29 Iloprost for the treatment of frostbite: a scoping review Gauthier, Josianne Morris-Janzen, Dunavan Poole, Alexander Int J Circumpolar Health Arctic Military Conference in Cold Weather Medicine We performed a scoping review to identify the extent of the literature describing the use of iloprost in the treatment of frostbite. Iloprost is a stable synthetic analog of prostaglandin I(2). As a potent inhibitor of platelet aggregation and vasodilator, it has been used to address the post-rewarming reperfusion injury in frostbite. The search using iloprost and frostbite as key words and MeSH terms yielded 200 articles. We included in our review the literature examining iloprost for the treatment of frostbite in humans in the form of primary research, conference proceedings and abstracts. Twenty studies published from 1994 to 2022 were selected for analysis. The majority were retrospective case series consisting of a homogeneous population of mountain sport enthusiasts. A total of 254 patients and over 1000 frostbitten digits were included among the 20 studies. The larger case series demonstrated a decrease in amputation rates relative to untreated patients. Primary gaps in the literature include a paucity of randomised trials and relatively limited study populations to date. While the case evidence is promising, a multi-centre collaboration would be crucial to adequately power prospective randomised studies to definitively determine if iloprost has a role in the treatment of frostbite. Taylor & Francis 2023-03-26 /pmc/articles/PMC10044161/ /pubmed/36966492 http://dx.doi.org/10.1080/22423982.2023.2189552 Text en © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
spellingShingle Arctic Military Conference in Cold Weather Medicine
Gauthier, Josianne
Morris-Janzen, Dunavan
Poole, Alexander
Iloprost for the treatment of frostbite: a scoping review
title Iloprost for the treatment of frostbite: a scoping review
title_full Iloprost for the treatment of frostbite: a scoping review
title_fullStr Iloprost for the treatment of frostbite: a scoping review
title_full_unstemmed Iloprost for the treatment of frostbite: a scoping review
title_short Iloprost for the treatment of frostbite: a scoping review
title_sort iloprost for the treatment of frostbite: a scoping review
topic Arctic Military Conference in Cold Weather Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10044161/
https://www.ncbi.nlm.nih.gov/pubmed/36966492
http://dx.doi.org/10.1080/22423982.2023.2189552
work_keys_str_mv AT gauthierjosianne iloprostforthetreatmentoffrostbiteascopingreview
AT morrisjanzendunavan iloprostforthetreatmentoffrostbiteascopingreview
AT poolealexander iloprostforthetreatmentoffrostbiteascopingreview