Cargando…
Glomerulosclerosis is a prognostic risk factor in patients with membranous nephropathy and non-nephrotic proteinuria
OBJECTIVE: To explore the predictive value of the proportion of glomerulosclerosis (GS) incidences on the progression of membranous nephropathy with non-nephrotic proteinuria (NNP). METHODS: This study was a single-center, retrospective, cohort study. Patients with biopsy-proven idiopathic membranou...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10044162/ https://www.ncbi.nlm.nih.gov/pubmed/36967636 http://dx.doi.org/10.1080/0886022X.2023.2188088 |
_version_ | 1784913306811629568 |
---|---|
author | Sun, Jing Li, Mengfei Zhu, Qianshen Jia, Yuanyuan Tian, Jia Zhang, Chao Du, Xuanyi |
author_facet | Sun, Jing Li, Mengfei Zhu, Qianshen Jia, Yuanyuan Tian, Jia Zhang, Chao Du, Xuanyi |
author_sort | Sun, Jing |
collection | PubMed |
description | OBJECTIVE: To explore the predictive value of the proportion of glomerulosclerosis (GS) incidences on the progression of membranous nephropathy with non-nephrotic proteinuria (NNP). METHODS: This study was a single-center, retrospective, cohort study. Patients with biopsy-proven idiopathic membranous nephropathy were divided into three groups based on the proportion of glomerular sclerosis, and their demographic, clinical, and pathological data were compared. The proportions of primary and secondary endpoints were recorded, and the relationship between GS and primary outcomes (progression to nephrotic syndrome, complete remission, and persistent NNP) and the renal composite endpoint was analyzed. RESULTS: A total of 112 patients were divided into three groups according to the proportions of glomerulosclerosis. The median follow-up time was 26.5 (13–51) months. There were significant differences in blood pressure (p < 0.01), renal interstitial lesions (p < 0.0001), and primary endpoints (p = 0.005). The survival analysis showed that prognosis was significantly worse in patients with a high proportion of GS than in those patients with a middle and low proportion of GS (p < 0.001). The Cox multivariate analysis showed that after adjusting for age, sex, BP, 24-h urinary protein, serum creatinine, treatment scheme, and pathological factors, the risk of renal composite outcome in the low proportion group was 0.076 times higher than that in the high proportion group (p = 0.009, HR = 0.076, 95% CI: 0.011–0.532). CONCLUSION: A high level of glomerulosclerosis was an independent risk factor for the prognosis of patients with membranous nephropathy with non-nephrotic proteinuria. |
format | Online Article Text |
id | pubmed-10044162 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-100441622023-03-29 Glomerulosclerosis is a prognostic risk factor in patients with membranous nephropathy and non-nephrotic proteinuria Sun, Jing Li, Mengfei Zhu, Qianshen Jia, Yuanyuan Tian, Jia Zhang, Chao Du, Xuanyi Ren Fail Clinical Study OBJECTIVE: To explore the predictive value of the proportion of glomerulosclerosis (GS) incidences on the progression of membranous nephropathy with non-nephrotic proteinuria (NNP). METHODS: This study was a single-center, retrospective, cohort study. Patients with biopsy-proven idiopathic membranous nephropathy were divided into three groups based on the proportion of glomerular sclerosis, and their demographic, clinical, and pathological data were compared. The proportions of primary and secondary endpoints were recorded, and the relationship between GS and primary outcomes (progression to nephrotic syndrome, complete remission, and persistent NNP) and the renal composite endpoint was analyzed. RESULTS: A total of 112 patients were divided into three groups according to the proportions of glomerulosclerosis. The median follow-up time was 26.5 (13–51) months. There were significant differences in blood pressure (p < 0.01), renal interstitial lesions (p < 0.0001), and primary endpoints (p = 0.005). The survival analysis showed that prognosis was significantly worse in patients with a high proportion of GS than in those patients with a middle and low proportion of GS (p < 0.001). The Cox multivariate analysis showed that after adjusting for age, sex, BP, 24-h urinary protein, serum creatinine, treatment scheme, and pathological factors, the risk of renal composite outcome in the low proportion group was 0.076 times higher than that in the high proportion group (p = 0.009, HR = 0.076, 95% CI: 0.011–0.532). CONCLUSION: A high level of glomerulosclerosis was an independent risk factor for the prognosis of patients with membranous nephropathy with non-nephrotic proteinuria. Taylor & Francis 2023-03-26 /pmc/articles/PMC10044162/ /pubmed/36967636 http://dx.doi.org/10.1080/0886022X.2023.2188088 Text en © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent. |
spellingShingle | Clinical Study Sun, Jing Li, Mengfei Zhu, Qianshen Jia, Yuanyuan Tian, Jia Zhang, Chao Du, Xuanyi Glomerulosclerosis is a prognostic risk factor in patients with membranous nephropathy and non-nephrotic proteinuria |
title | Glomerulosclerosis is a prognostic risk factor in patients with membranous nephropathy and non-nephrotic proteinuria |
title_full | Glomerulosclerosis is a prognostic risk factor in patients with membranous nephropathy and non-nephrotic proteinuria |
title_fullStr | Glomerulosclerosis is a prognostic risk factor in patients with membranous nephropathy and non-nephrotic proteinuria |
title_full_unstemmed | Glomerulosclerosis is a prognostic risk factor in patients with membranous nephropathy and non-nephrotic proteinuria |
title_short | Glomerulosclerosis is a prognostic risk factor in patients with membranous nephropathy and non-nephrotic proteinuria |
title_sort | glomerulosclerosis is a prognostic risk factor in patients with membranous nephropathy and non-nephrotic proteinuria |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10044162/ https://www.ncbi.nlm.nih.gov/pubmed/36967636 http://dx.doi.org/10.1080/0886022X.2023.2188088 |
work_keys_str_mv | AT sunjing glomerulosclerosisisaprognosticriskfactorinpatientswithmembranousnephropathyandnonnephroticproteinuria AT limengfei glomerulosclerosisisaprognosticriskfactorinpatientswithmembranousnephropathyandnonnephroticproteinuria AT zhuqianshen glomerulosclerosisisaprognosticriskfactorinpatientswithmembranousnephropathyandnonnephroticproteinuria AT jiayuanyuan glomerulosclerosisisaprognosticriskfactorinpatientswithmembranousnephropathyandnonnephroticproteinuria AT tianjia glomerulosclerosisisaprognosticriskfactorinpatientswithmembranousnephropathyandnonnephroticproteinuria AT zhangchao glomerulosclerosisisaprognosticriskfactorinpatientswithmembranousnephropathyandnonnephroticproteinuria AT duxuanyi glomerulosclerosisisaprognosticriskfactorinpatientswithmembranousnephropathyandnonnephroticproteinuria |