Preparation of nanofibrous poly (L-lactic acid) scaffolds using the thermally induced phase separation technique in dioxane/polyethylene glycol solution

Porous nanofibrous poly (L-lactic acid) (PLLA) scaffolds were fabricated in combination with a thermally induced phase separation technique using a dioxane/polyethylene glycol (PEG) system. The effect of factors such as molecular weight of PEG, aging treatment, aging or gelation temperature, and the...

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Detalles Bibliográficos
Autores principales: Zhang, Tao, Chen, Kangyao, Wu, Xing, Xiao, Xiufeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Full Length Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10044164/
https://www.ncbi.nlm.nih.gov/pubmed/36998721
http://dx.doi.org/10.1080/15685551.2023.2194175
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author Zhang, Tao
Chen, Kangyao
Wu, Xing
Xiao, Xiufeng
author_facet Zhang, Tao
Chen, Kangyao
Wu, Xing
Xiao, Xiufeng
author_sort Zhang, Tao
collection PubMed
description Porous nanofibrous poly (L-lactic acid) (PLLA) scaffolds were fabricated in combination with a thermally induced phase separation technique using a dioxane/polyethylene glycol (PEG) system. The effect of factors such as molecular weight of PEG, aging treatment, aging or gelation temperature, and the ratio of PEG to dioxane were investigated. The results revealed that all scaffolds had high porosity, and had a significant impact on the formation of nanofibrous structures. The decrease in the molecular weight and aging or gelation temperature leads to a thinner and more uniform fibrous structure.
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spelling pubmed-100441642023-03-29 Preparation of nanofibrous poly (L-lactic acid) scaffolds using the thermally induced phase separation technique in dioxane/polyethylene glycol solution Zhang, Tao Chen, Kangyao Wu, Xing Xiao, Xiufeng Des Monomers Polym Full Length Article Porous nanofibrous poly (L-lactic acid) (PLLA) scaffolds were fabricated in combination with a thermally induced phase separation technique using a dioxane/polyethylene glycol (PEG) system. The effect of factors such as molecular weight of PEG, aging treatment, aging or gelation temperature, and the ratio of PEG to dioxane were investigated. The results revealed that all scaffolds had high porosity, and had a significant impact on the formation of nanofibrous structures. The decrease in the molecular weight and aging or gelation temperature leads to a thinner and more uniform fibrous structure. Taylor & Francis 2023-03-26 /pmc/articles/PMC10044164/ /pubmed/36998721 http://dx.doi.org/10.1080/15685551.2023.2194175 Text en © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
spellingShingle Full Length Article
Zhang, Tao
Chen, Kangyao
Wu, Xing
Xiao, Xiufeng
Preparation of nanofibrous poly (L-lactic acid) scaffolds using the thermally induced phase separation technique in dioxane/polyethylene glycol solution
title Preparation of nanofibrous poly (L-lactic acid) scaffolds using the thermally induced phase separation technique in dioxane/polyethylene glycol solution
title_full Preparation of nanofibrous poly (L-lactic acid) scaffolds using the thermally induced phase separation technique in dioxane/polyethylene glycol solution
title_fullStr Preparation of nanofibrous poly (L-lactic acid) scaffolds using the thermally induced phase separation technique in dioxane/polyethylene glycol solution
title_full_unstemmed Preparation of nanofibrous poly (L-lactic acid) scaffolds using the thermally induced phase separation technique in dioxane/polyethylene glycol solution
title_short Preparation of nanofibrous poly (L-lactic acid) scaffolds using the thermally induced phase separation technique in dioxane/polyethylene glycol solution
title_sort preparation of nanofibrous poly (l-lactic acid) scaffolds using the thermally induced phase separation technique in dioxane/polyethylene glycol solution
topic Full Length Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10044164/
https://www.ncbi.nlm.nih.gov/pubmed/36998721
http://dx.doi.org/10.1080/15685551.2023.2194175
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