Priming of the murine mammary gland with Staphylococcus chromogenes IM reduces bacterial growth of Streptococcus uberis: a proof-of-concept study

Streptococcus uberis is a major causative agent of bovine mastitis, an inflammation of the mammary gland with substantial economic consequences. To reduce antibiotic use in animal agriculture, alternative strategies to treat or prevent mastitis are being investigated. Bovine-associated non-aureus st...

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Autores principales: Vander Elst, Niels, Bellemans, Julie, Steenbrugge, Jonas, Geeroms, Chloë, Breyne, Koen, Piepers, Sofie, Toledo-Silva, Bruno, de Souza, Fernando Nogueira, Haesebrouck, Freddy, De Vliegher, Sarne, Meyer, Evelyne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10044423/
https://www.ncbi.nlm.nih.gov/pubmed/36973819
http://dx.doi.org/10.1186/s13567-023-01156-y
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author Vander Elst, Niels
Bellemans, Julie
Steenbrugge, Jonas
Geeroms, Chloë
Breyne, Koen
Piepers, Sofie
Toledo-Silva, Bruno
de Souza, Fernando Nogueira
Haesebrouck, Freddy
De Vliegher, Sarne
Meyer, Evelyne
author_facet Vander Elst, Niels
Bellemans, Julie
Steenbrugge, Jonas
Geeroms, Chloë
Breyne, Koen
Piepers, Sofie
Toledo-Silva, Bruno
de Souza, Fernando Nogueira
Haesebrouck, Freddy
De Vliegher, Sarne
Meyer, Evelyne
author_sort Vander Elst, Niels
collection PubMed
description Streptococcus uberis is a major causative agent of bovine mastitis, an inflammation of the mammary gland with substantial economic consequences. To reduce antibiotic use in animal agriculture, alternative strategies to treat or prevent mastitis are being investigated. Bovine-associated non-aureus staphylococci are proposed in that respect due to their capacity to inhibit the in vitro growth of S. uberis. We demonstrate that priming the murine mammary gland with Staphylococcus chromogenes IM reduces S. uberis growth in comparison with non-primed glands. The innate immune system is activated by increasing IL-8 and LCN2, which may explain this decreased growth.
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spelling pubmed-100444232023-03-29 Priming of the murine mammary gland with Staphylococcus chromogenes IM reduces bacterial growth of Streptococcus uberis: a proof-of-concept study Vander Elst, Niels Bellemans, Julie Steenbrugge, Jonas Geeroms, Chloë Breyne, Koen Piepers, Sofie Toledo-Silva, Bruno de Souza, Fernando Nogueira Haesebrouck, Freddy De Vliegher, Sarne Meyer, Evelyne Vet Res Short Report Streptococcus uberis is a major causative agent of bovine mastitis, an inflammation of the mammary gland with substantial economic consequences. To reduce antibiotic use in animal agriculture, alternative strategies to treat or prevent mastitis are being investigated. Bovine-associated non-aureus staphylococci are proposed in that respect due to their capacity to inhibit the in vitro growth of S. uberis. We demonstrate that priming the murine mammary gland with Staphylococcus chromogenes IM reduces S. uberis growth in comparison with non-primed glands. The innate immune system is activated by increasing IL-8 and LCN2, which may explain this decreased growth. BioMed Central 2023-03-27 2023 /pmc/articles/PMC10044423/ /pubmed/36973819 http://dx.doi.org/10.1186/s13567-023-01156-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Short Report
Vander Elst, Niels
Bellemans, Julie
Steenbrugge, Jonas
Geeroms, Chloë
Breyne, Koen
Piepers, Sofie
Toledo-Silva, Bruno
de Souza, Fernando Nogueira
Haesebrouck, Freddy
De Vliegher, Sarne
Meyer, Evelyne
Priming of the murine mammary gland with Staphylococcus chromogenes IM reduces bacterial growth of Streptococcus uberis: a proof-of-concept study
title Priming of the murine mammary gland with Staphylococcus chromogenes IM reduces bacterial growth of Streptococcus uberis: a proof-of-concept study
title_full Priming of the murine mammary gland with Staphylococcus chromogenes IM reduces bacterial growth of Streptococcus uberis: a proof-of-concept study
title_fullStr Priming of the murine mammary gland with Staphylococcus chromogenes IM reduces bacterial growth of Streptococcus uberis: a proof-of-concept study
title_full_unstemmed Priming of the murine mammary gland with Staphylococcus chromogenes IM reduces bacterial growth of Streptococcus uberis: a proof-of-concept study
title_short Priming of the murine mammary gland with Staphylococcus chromogenes IM reduces bacterial growth of Streptococcus uberis: a proof-of-concept study
title_sort priming of the murine mammary gland with staphylococcus chromogenes im reduces bacterial growth of streptococcus uberis: a proof-of-concept study
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10044423/
https://www.ncbi.nlm.nih.gov/pubmed/36973819
http://dx.doi.org/10.1186/s13567-023-01156-y
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