Evolutionary and Genomic Diversity of True Polyploidy in Tetrapods

SIMPLE SUMMARY: Polyploidization, or whole-genome duplication (WGD), represents a dramatic event in evolution. Although its occurrence is much rarer in animals than in plants, distinct WGDs characterize the stem lineages of vertebrates and teleosts. In tetrapods, true polyploids have been described in all major groups and include a wide range of genomic configurations and modes of reproduction. In this work, we provide a comprehensive report on the presence of different types of polyploidy in tetrapods, with a particular focus on its genomic, evolutionary, and ecological diversity. We also describe the main routes of the formation of neopolyploids and discuss the two competing hypotheses that consider polyploidy either as a major force in evolution or, mainly, as an evolutionary dead end. ABSTRACT: True polyploid organisms have more than two chromosome sets in their somatic and germline cells. Polyploidy is a major evolutionary force and has played a significant role in the early genomic evolution of plants, different invertebrate taxa, chordates, and teleosts. However, the contribution of polyploidy to the generation of new genomic, ecological, and species diversity in tetrapods has traditionally been underestimated. Indeed, polyploidy represents an important pathway of genomic evolution, occurring in most higher-taxa tetrapods and displaying a variety of different forms, genomic configurations, and biological implications. Herein, we report and discuss the available information on the different origins and evolutionary and ecological significance of true polyploidy in tetrapods. Among the main tetrapod lineages, modern amphibians have an unparalleled diversity of polyploids and, until recently, they were considered to be the only vertebrates with closely related diploid and polyploid bisexual species or populations. In reptiles, polyploidy was thought to be restricted to squamates and associated with parthenogenesis. In birds and mammals, true polyploidy has generally been considered absent (non-tolerated). These views are being changed due to an accumulation of new data, and the impact as well as the different evolutionary and ecological implications of polyploidy in tetrapods, deserve a broader evaluation.