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Persistent Methicillin-Resistant Staphylococcus aureus Bacteremia: Host, Pathogen, and Treatment

Methicillin-resistant Staphylococcus aureus (MRSA) is a devastating pathogen responsible for a variety of life-threatening infections. A distinctive characteristic of this pathogen is its ability to persist in the bloodstream for several days despite seemingly appropriate antibiotics. Persistent MRS...

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Autores principales: Parsons, Joshua B., Westgeest, Annette C., Conlon, Brian P., Fowler, Vance G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10044482/
https://www.ncbi.nlm.nih.gov/pubmed/36978320
http://dx.doi.org/10.3390/antibiotics12030455
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author Parsons, Joshua B.
Westgeest, Annette C.
Conlon, Brian P.
Fowler, Vance G.
author_facet Parsons, Joshua B.
Westgeest, Annette C.
Conlon, Brian P.
Fowler, Vance G.
author_sort Parsons, Joshua B.
collection PubMed
description Methicillin-resistant Staphylococcus aureus (MRSA) is a devastating pathogen responsible for a variety of life-threatening infections. A distinctive characteristic of this pathogen is its ability to persist in the bloodstream for several days despite seemingly appropriate antibiotics. Persistent MRSA bacteremia is common and is associated with poor clinical outcomes. The etiology of persistent MRSA bacteremia is a result of the complex interplay between the host, the pathogen, and the antibiotic used to treat the infection. In this review, we explore the factors related to each component of the host–pathogen interaction and discuss the clinical relevance of each element. Next, we discuss the treatment options and diagnostic approaches for the management of persistent MRSA bacteremia.
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spelling pubmed-100444822023-03-29 Persistent Methicillin-Resistant Staphylococcus aureus Bacteremia: Host, Pathogen, and Treatment Parsons, Joshua B. Westgeest, Annette C. Conlon, Brian P. Fowler, Vance G. Antibiotics (Basel) Review Methicillin-resistant Staphylococcus aureus (MRSA) is a devastating pathogen responsible for a variety of life-threatening infections. A distinctive characteristic of this pathogen is its ability to persist in the bloodstream for several days despite seemingly appropriate antibiotics. Persistent MRSA bacteremia is common and is associated with poor clinical outcomes. The etiology of persistent MRSA bacteremia is a result of the complex interplay between the host, the pathogen, and the antibiotic used to treat the infection. In this review, we explore the factors related to each component of the host–pathogen interaction and discuss the clinical relevance of each element. Next, we discuss the treatment options and diagnostic approaches for the management of persistent MRSA bacteremia. MDPI 2023-02-24 /pmc/articles/PMC10044482/ /pubmed/36978320 http://dx.doi.org/10.3390/antibiotics12030455 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Parsons, Joshua B.
Westgeest, Annette C.
Conlon, Brian P.
Fowler, Vance G.
Persistent Methicillin-Resistant Staphylococcus aureus Bacteremia: Host, Pathogen, and Treatment
title Persistent Methicillin-Resistant Staphylococcus aureus Bacteremia: Host, Pathogen, and Treatment
title_full Persistent Methicillin-Resistant Staphylococcus aureus Bacteremia: Host, Pathogen, and Treatment
title_fullStr Persistent Methicillin-Resistant Staphylococcus aureus Bacteremia: Host, Pathogen, and Treatment
title_full_unstemmed Persistent Methicillin-Resistant Staphylococcus aureus Bacteremia: Host, Pathogen, and Treatment
title_short Persistent Methicillin-Resistant Staphylococcus aureus Bacteremia: Host, Pathogen, and Treatment
title_sort persistent methicillin-resistant staphylococcus aureus bacteremia: host, pathogen, and treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10044482/
https://www.ncbi.nlm.nih.gov/pubmed/36978320
http://dx.doi.org/10.3390/antibiotics12030455
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