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Green Antimicrobials as Therapeutic Agents for Diabetic Foot Ulcers

Diabetic foot ulcers (DFU) are one of the most serious and devastating complications of diabetes and account for a significant decrease in quality of life and costly healthcare expenses worldwide. This condition affects around 15% of diabetic patients and is one of the leading causes of lower limb a...

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Autores principales: Teixeira, Ines D., Carvalho, Eugenia, Leal, Ermelindo C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10044531/
https://www.ncbi.nlm.nih.gov/pubmed/36978333
http://dx.doi.org/10.3390/antibiotics12030467
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author Teixeira, Ines D.
Carvalho, Eugenia
Leal, Ermelindo C.
author_facet Teixeira, Ines D.
Carvalho, Eugenia
Leal, Ermelindo C.
author_sort Teixeira, Ines D.
collection PubMed
description Diabetic foot ulcers (DFU) are one of the most serious and devastating complications of diabetes and account for a significant decrease in quality of life and costly healthcare expenses worldwide. This condition affects around 15% of diabetic patients and is one of the leading causes of lower limb amputations. DFUs generally present poor clinical outcomes, mainly due to the impaired healing process and the elevated risk of microbial infections which leads to tissue damage. Nowadays, antimicrobial resistance poses a rising threat to global health, thus hampering DFU treatment and care. Faced with this reality, it is pivotal to find greener and less environmentally impactful alternatives for fighting these resistant microbes. Antimicrobial peptides are small molecules that play a crucial role in the innate immune system of the host and can be found in nature. Some of these molecules have shown broad-spectrum antimicrobial properties and wound-healing activity, making them good potential therapeutic compounds to treat DFUs. This review aims to describe antimicrobial peptides derived from green, eco-friendly processes that can be used as potential therapeutic compounds to treat DFUs, thereby granting a better quality of life to patients and their families while protecting our fundamental bio-resources.
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spelling pubmed-100445312023-03-29 Green Antimicrobials as Therapeutic Agents for Diabetic Foot Ulcers Teixeira, Ines D. Carvalho, Eugenia Leal, Ermelindo C. Antibiotics (Basel) Review Diabetic foot ulcers (DFU) are one of the most serious and devastating complications of diabetes and account for a significant decrease in quality of life and costly healthcare expenses worldwide. This condition affects around 15% of diabetic patients and is one of the leading causes of lower limb amputations. DFUs generally present poor clinical outcomes, mainly due to the impaired healing process and the elevated risk of microbial infections which leads to tissue damage. Nowadays, antimicrobial resistance poses a rising threat to global health, thus hampering DFU treatment and care. Faced with this reality, it is pivotal to find greener and less environmentally impactful alternatives for fighting these resistant microbes. Antimicrobial peptides are small molecules that play a crucial role in the innate immune system of the host and can be found in nature. Some of these molecules have shown broad-spectrum antimicrobial properties and wound-healing activity, making them good potential therapeutic compounds to treat DFUs. This review aims to describe antimicrobial peptides derived from green, eco-friendly processes that can be used as potential therapeutic compounds to treat DFUs, thereby granting a better quality of life to patients and their families while protecting our fundamental bio-resources. MDPI 2023-02-25 /pmc/articles/PMC10044531/ /pubmed/36978333 http://dx.doi.org/10.3390/antibiotics12030467 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Teixeira, Ines D.
Carvalho, Eugenia
Leal, Ermelindo C.
Green Antimicrobials as Therapeutic Agents for Diabetic Foot Ulcers
title Green Antimicrobials as Therapeutic Agents for Diabetic Foot Ulcers
title_full Green Antimicrobials as Therapeutic Agents for Diabetic Foot Ulcers
title_fullStr Green Antimicrobials as Therapeutic Agents for Diabetic Foot Ulcers
title_full_unstemmed Green Antimicrobials as Therapeutic Agents for Diabetic Foot Ulcers
title_short Green Antimicrobials as Therapeutic Agents for Diabetic Foot Ulcers
title_sort green antimicrobials as therapeutic agents for diabetic foot ulcers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10044531/
https://www.ncbi.nlm.nih.gov/pubmed/36978333
http://dx.doi.org/10.3390/antibiotics12030467
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