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Cutibacterium spp. Infections after Instrumented Spine Surgery Have a Good Prognosis Regardless of Rifampin Use: A Cross-Sectional Study

Infection after spinal instrumentation (IASI) by Cutibacterium spp. is being more frequently reported. The aim of this study was to analyse the incidence, risk factors, clinical characteristics, and outcome of a Cutibacterium spp. IASI (CG) compared with non-Cutibacterium IASI (NCG) infections, with...

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Autores principales: Núñez-Pereira, Susana, Benavent, Eva, Ulldemolins, Marta, Sobrino-Díaz, Beatriz, Iribarren, José A., Escudero-Sánchez, Rosa, Del Toro, María Dolores, Nodar, Andrés, Sorli, Luisa, Bahamonde, Alberto, Vilchez, Helem H., Gasch, Oriol, Muñez, Elena, Rodríguez-Montserrat, David, García-País, María José, Haddad, Sleiman, Sellarès-Nadal, Julia, Murillo, Oscar, Rodríguez-Pardo, Dolors
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10044575/
https://www.ncbi.nlm.nih.gov/pubmed/36978385
http://dx.doi.org/10.3390/antibiotics12030518
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author Núñez-Pereira, Susana
Benavent, Eva
Ulldemolins, Marta
Sobrino-Díaz, Beatriz
Iribarren, José A.
Escudero-Sánchez, Rosa
Del Toro, María Dolores
Nodar, Andrés
Sorli, Luisa
Bahamonde, Alberto
Vilchez, Helem H.
Gasch, Oriol
Muñez, Elena
Rodríguez-Montserrat, David
García-País, María José
Haddad, Sleiman
Sellarès-Nadal, Julia
Murillo, Oscar
Rodríguez-Pardo, Dolors
author_facet Núñez-Pereira, Susana
Benavent, Eva
Ulldemolins, Marta
Sobrino-Díaz, Beatriz
Iribarren, José A.
Escudero-Sánchez, Rosa
Del Toro, María Dolores
Nodar, Andrés
Sorli, Luisa
Bahamonde, Alberto
Vilchez, Helem H.
Gasch, Oriol
Muñez, Elena
Rodríguez-Montserrat, David
García-País, María José
Haddad, Sleiman
Sellarès-Nadal, Julia
Murillo, Oscar
Rodríguez-Pardo, Dolors
author_sort Núñez-Pereira, Susana
collection PubMed
description Infection after spinal instrumentation (IASI) by Cutibacterium spp. is being more frequently reported. The aim of this study was to analyse the incidence, risk factors, clinical characteristics, and outcome of a Cutibacterium spp. IASI (CG) compared with non-Cutibacterium IASI (NCG) infections, with an additional focus on the role of rifampin in the treatment. All patients from a multicentre, retrospective, observational study with a confirmed IASI between January 2010 and December 2016 were divided into two groups: (CG and NCG) IASI. Baseline, medical, surgical, infection treatment, and follow-up data were compared for both groups. In total, 411 patients were included: 27 CG and 384 NCG. The CG patients were significantly younger. They had a longer median time to diagnosis (23 vs. 13 days) (p = 0.025), although 55.6% debuted within the first month after surgery. Cutibacterium patients were more likely to have the implant removed (29.6% vs. 12.8%; p = 0.014) and received shorter antibiotic regimens (p = 0.014). In 33% of Cutibacterium cases, rifampin was added to the baseline therapy. None of the 27 infections resulted in treatment failure during follow-up regardless of rifampin use. Cutibacterium spp. is associated with a younger age and may cause both early and late IASIs. In our experience, the use of rifampin to improve the outcome in the treatment of a Cutibacterium spp. IASI is not relevant since, in our series, none of the cases had therapeutic failure regardless of the use of rifampin.
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spelling pubmed-100445752023-03-29 Cutibacterium spp. Infections after Instrumented Spine Surgery Have a Good Prognosis Regardless of Rifampin Use: A Cross-Sectional Study Núñez-Pereira, Susana Benavent, Eva Ulldemolins, Marta Sobrino-Díaz, Beatriz Iribarren, José A. Escudero-Sánchez, Rosa Del Toro, María Dolores Nodar, Andrés Sorli, Luisa Bahamonde, Alberto Vilchez, Helem H. Gasch, Oriol Muñez, Elena Rodríguez-Montserrat, David García-País, María José Haddad, Sleiman Sellarès-Nadal, Julia Murillo, Oscar Rodríguez-Pardo, Dolors Antibiotics (Basel) Article Infection after spinal instrumentation (IASI) by Cutibacterium spp. is being more frequently reported. The aim of this study was to analyse the incidence, risk factors, clinical characteristics, and outcome of a Cutibacterium spp. IASI (CG) compared with non-Cutibacterium IASI (NCG) infections, with an additional focus on the role of rifampin in the treatment. All patients from a multicentre, retrospective, observational study with a confirmed IASI between January 2010 and December 2016 were divided into two groups: (CG and NCG) IASI. Baseline, medical, surgical, infection treatment, and follow-up data were compared for both groups. In total, 411 patients were included: 27 CG and 384 NCG. The CG patients were significantly younger. They had a longer median time to diagnosis (23 vs. 13 days) (p = 0.025), although 55.6% debuted within the first month after surgery. Cutibacterium patients were more likely to have the implant removed (29.6% vs. 12.8%; p = 0.014) and received shorter antibiotic regimens (p = 0.014). In 33% of Cutibacterium cases, rifampin was added to the baseline therapy. None of the 27 infections resulted in treatment failure during follow-up regardless of rifampin use. Cutibacterium spp. is associated with a younger age and may cause both early and late IASIs. In our experience, the use of rifampin to improve the outcome in the treatment of a Cutibacterium spp. IASI is not relevant since, in our series, none of the cases had therapeutic failure regardless of the use of rifampin. MDPI 2023-03-04 /pmc/articles/PMC10044575/ /pubmed/36978385 http://dx.doi.org/10.3390/antibiotics12030518 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Núñez-Pereira, Susana
Benavent, Eva
Ulldemolins, Marta
Sobrino-Díaz, Beatriz
Iribarren, José A.
Escudero-Sánchez, Rosa
Del Toro, María Dolores
Nodar, Andrés
Sorli, Luisa
Bahamonde, Alberto
Vilchez, Helem H.
Gasch, Oriol
Muñez, Elena
Rodríguez-Montserrat, David
García-País, María José
Haddad, Sleiman
Sellarès-Nadal, Julia
Murillo, Oscar
Rodríguez-Pardo, Dolors
Cutibacterium spp. Infections after Instrumented Spine Surgery Have a Good Prognosis Regardless of Rifampin Use: A Cross-Sectional Study
title Cutibacterium spp. Infections after Instrumented Spine Surgery Have a Good Prognosis Regardless of Rifampin Use: A Cross-Sectional Study
title_full Cutibacterium spp. Infections after Instrumented Spine Surgery Have a Good Prognosis Regardless of Rifampin Use: A Cross-Sectional Study
title_fullStr Cutibacterium spp. Infections after Instrumented Spine Surgery Have a Good Prognosis Regardless of Rifampin Use: A Cross-Sectional Study
title_full_unstemmed Cutibacterium spp. Infections after Instrumented Spine Surgery Have a Good Prognosis Regardless of Rifampin Use: A Cross-Sectional Study
title_short Cutibacterium spp. Infections after Instrumented Spine Surgery Have a Good Prognosis Regardless of Rifampin Use: A Cross-Sectional Study
title_sort cutibacterium spp. infections after instrumented spine surgery have a good prognosis regardless of rifampin use: a cross-sectional study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10044575/
https://www.ncbi.nlm.nih.gov/pubmed/36978385
http://dx.doi.org/10.3390/antibiotics12030518
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